eng Oriental Scientific Publishing Company Biomedical and Pharmacology Journal 0974-6242 2017-06-20 10 2 667 673 10.13005/bpj/1154 15434 article Sukohar Asep 1 Herawati Hening 2 Sari Gema P. 3 Setiawan Gigih 1 Morfi Chicy Widya 1 Sahidin 4 Faculty of Medicine, Lampung University, Lampung 35145, Indonesia. Department of Research and Development, Dharmais Cancer Hospital, Jakarta 11420, Indonesia. Departemen of Immunology Faculty Of Medicine, Indonesia University, Jakarta 10430, Indonesia. Faculty of Pharmacy, Haluoleo University, Kendari 93232, Indonesia. Jatrophone is an isolated compound from Jatropha gossypifolia’s sterm bark plant which have cytotoxic activities against human cell lines cancer. This project studied about cytotoxic evaluation of jatrophone against human cell line liver cancer Hep G2 1886. We also aim to discover jatrophone as new anticancer agent against hepatocellular carcinoma. The potential anticancer activity was measured using cultured cancer human cell line Hep G2 from Tohuku Uiversity of Japan. And  the cytotoxic properties of jatrophone toward human cell line liver cancer Hep G2 1886 was evaluated  using MTT assays. The results of the study are  cytotoxic potency of jatrophone were indicated by IC50 value  against cell line Liver Cancer Hep G2 1886 is 3.2 µM, meanwhile IC50 value of jatrophone against another cell lines cancer such as human colon cancer line WiDr, cervix cancer cell line HeLa and stomach cancer AGS are 8.97, 5.13 and 2,5 µM respectively. Jatrophone had better anticancer potency activites against cell line  liver cancer Hep G2 than WiDr and HeLa cell lines cancer. In addition jatrophone also had better anticancer activity against cell line cancer liver Hep G2 than standard anticancer such as sorafenib and ATO (Arsenic Trioxyde). https://biomedpharmajournal.org/vol10no2/anticancer-activity-of-jatrophone-an-isolated-compound-from-jatropha-gossypifolia-plant-against-hepatocellular-cancer-cell-hep-g2-1886/ Hep G2 1886 Jatrophone MTT{3-(4 5-dimethylthiazol-2-yl)-2 5-diphenyltetrazolium bromide} assay