eng Oriental Scientific Publishing Company Biomedical and Pharmacology Journal 0974-6242 2017-06-20 10 2 787 793 10.13005/bpj/1169 14813 article Kajaria Divya 1 Tripathi J. S. 1 Tiwari S. K. 1 Department of Kayachikitsa, Faculty of Ayurveda, Institute of Medical Sciences, B.H.U.- 221005, Varanasi, India. The present study aims to search a drug that acts on platelet aggregation to validate the fact that preventing platelet aggregation is helpful in successful management of bronchial asthma in addition with the effect on previously proved mechanism.  With this aim it was planned to search the effect of a polyherbal drug - Shirishadi on platelet aggregation. It is worthy here to mention that this drug (Shirishadi) is chosen on the basis of clinical evidence suggesting its potent anti-asthmatic effect. Anti-platelet property of Shirishadi polyherbal compound was evaluated using thrombin induced platelet aggregation isolated from human blood (collected from healthy volunteers) by differential centrifugation. Under in vitro conditions, 15 min pre-incubation with the  Shirishadi polyherbal compound (200µg/ml) significantly (p< 0.001) inhibit thrombin- induced platelet aggregation. These findings suggest that Shirishadi, a polyherbal formulation possesses potent anti-platelet aggregation activity in the experimental models of in vitro platelet aggregation. https://biomedpharmajournal.org/vol10no2/anti-platelet-aggregating-activity-of-a-polyherbal-compound-shirishadi-in-vitro-study/ Bronchial asthma  Shirishadi  polyherbal compound Unhinged platelet aggregation