eng Oriental Scientific Publishing Company Biomedical and Pharmacology Journal 0974-6242 2017-03-25 10 1 01 07 10.13005/bpj/1074 14023 article Alireza Nazari 1,5 Atlas Mashayekhi Sardoo 2 Elnaz Tahmooresi Fard 3 Hossein Khorramdelazad 4,5 Gholamhossein Hassanshahi 5 Ali Esmaeili Nadimi 6,7 Department of Urology, Faculty of Medicine, University of Medical Science, Rafsanjan, Iran. School of Engineering and Design and Physical Sciences, Brunel University London, London, United Kingdom. Department of Biology, Faculty of Sciences, University of Guilan, Rasht, Iran. Department of Immunology, Faculty of Medicine Rafsanjan University of Medical Sciences, Rafsanjan, Iran. Molecular Medicine Research Center, Rafsanjan University of Medical Science, Rafsanjan, Iran. Department of Cardiology, Faculty of Medicine, University of Medical Science, Rafsanjan, Iran. Studies have shown that the soluble C-X-C chemokine ligand 16 (CXCL16), a scavenger receptor for oxidized low-density lipoproteins, plays an important role in acute coronary syndrome with atherogenic effects. This study aimed to discover the association between circulating CXCL16 levels in hemodialysis patients (HD patients) with cardiovascular disease (CVD). In this cross-sectional study, we enrolled Two hundred twenty subjects, which included 82 HD patients, 70 HD patients with CVD, and 68 healthy controls, who were referred to the Ali Ebn- Abitaleb Hospital, (Rafsanjan, Iran) from Sep 2014 to Feb 2016. Serum CXCL16 levels were measured by ELISA and other clinical parameters were examined based on standard methods. Our results indicated that serum CXCL16 levels were significantly increased in HD patients with CVD when compared with HD patients without CVD and healthy subjects (p < 0.05). Findings of this study demonstrated that the serum level of CXCL16 can be a potential predictor for the diagnosis of cardiovascular disease in HD patients. https://biomedpharmajournal.org/vol10no1/plasma-cxcl16-level-is-associated-with-cardiovascular-disease-in-iranian-hemodialysis-patients/ Cardiovascular Diseases CXCL16 chemokine Hemodialysis