eng Oriental Scientific Publishing Company Biomedical and Pharmacology Journal 0974-6242 2017-03-25 10 1 179 189 10.13005/bpj/1096 14071 article Anvar Elyasi 1,2 Marzieh Soheili 2 Khosro Setayeshi 2 Shirin Honarmand 1 Katayoun Derakhshandeh 3,4 Department of Surgery, Faculty of Medicine, Kurdistan University of Medical Sciences, Kurdistan, Iran. Department of Surgery, Faculty of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran. Department of Pharmaceutics, Faculty of Pharmacy, Hamedan University of Medical Sciences, Hamedan, Iran. Department of Pharmaceutics, Faculty of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah, Iran. Peritoneal adhesions are pathological fibrotic bands developing after mesothelial damage which causes different problems in the patients. The aim of this study was to compare the anti-adhesion efficacy of a herbal structure made from Psylium seeds with a commercially available formulation named Pluronic both in the form of hydrogel in a rat cecum abrasion model. The rat model utilized a cecal abrasion and abdominal wall insult surgical protocol. Psylium hydrogel treatment was applied by syringe to coat both the cecal and the abdominal wall insults, while other animals were treated with Pluronic applied to the cecal injury. Control animals did not receive any treatment. Animals were sacrificed after 21 days of laparotomy and adhesion severity was quantitatively graded according to macromorphological characteristics. Histological analysis was also performed for all animals. Psylium treated animals showed significantly lower adhesion scores than other groups (P<0.05), while Pluronic did not demonstrate any noticeable results. In conclusion, Psylium hydrogel showed a significantly decreased adhesion score compared with the Pluronic and control groups. However, Psylium compared with all adhesion formulations and barriers offer natural structure as well as ease of application and ability to conform to complex tissue geometries that could provide surgeons with another prophylactic treatment for preventing abdominal adhesions. https://biomedpharmajournal.org/vol10no1/adhesion-prevention-by-peritoneal-administration-of-herbal-hydrogel/ Peritoneal adhesion Psylium hydrogel herbal formulation