{"id":945,"date":"2015-02-16T06:55:41","date_gmt":"2015-02-16T06:55:41","guid":{"rendered":"http:\/\/biomedpharmajournal.org\/?p=945"},"modified":"2017-01-05T07:26:48","modified_gmt":"2017-01-05T07:26:48","slug":"rationality-of-ayurvedic-pharmaceutical-procedures","status":"publish","type":"post","link":"https:\/\/biomedpharmajournal.org\/staging\/vol2no2\/rationality-of-ayurvedic-pharmaceutical-procedures\/","title":{"rendered":"Rationality of Ayurvedic Pharmaceutical Procedures"},"content":{"rendered":"

Introduction <\/strong><\/p>\n

Notion of Ayurveda is framed upon \u2018Trisutra\u2019<\/em> (03 principles) viz. Hetu<\/em>, (cause of diseases) Linga<\/em> (Sign & Symptom) and Aushadha<\/em> (Medicines)1. In this system drugs having plant, animal or mineral origins are like and instrumental aid to a physician.<\/p>\n

Acharya Charaka was observed, in this world, no substance the may not be used as medicine of this or that purpose2. Purposiveness and rationality are the two parameters to judge and use of any substance as medicine. For better learning Ayurvedic formulations are mostly classified into two types; A.<\/em> single drug formulations and B.<\/em> compound drug formulations. Till today, about one thousand single drug and eight thousand compound formulations of recognize merit is in vogue. Again the formulations are grouped in two groups i.e. Kasthausadhi<\/em> (herbal formulation) and Rasausadhi<\/em> (herbomineral formulations). Rasa Shastra<\/em> (Ayurvedic Pharmaceutics) is named after mercury and allied minerals.<\/p>\n

Ayurvedic pharmaceutics is generally studied under two branches i.e. Rasa Shastra<\/em> (predominately processing of metals\/minerals) and Bhaishajya Kalpana<\/em> (processing of herbals and herbomineral compounds). Grossly Ayurvedic pharmaceutics dealt with collection and selection of drugs of herbal\/metal\/mineral origin, their processing, preservation, besides mode of administration and posology.<\/p>\n

Processing techniques converts original raw material into pharmacological active form. Usually processing techniques are by dilution, application of heat, cleansing, churning, storing, maturing, flavouring, preservation in container etc., knows as different Sanskaras<\/em>. Undergoing through<\/p>\n

different Sanskaras<\/em> (Pharmaceutical process) transformation of good pharmacological action takes place, in other words Sanskaras effects the changes of the property of a drug.<\/p>\n

Importance of pharmaceutical process<\/strong><\/p>\n

Even medicine that is not prepared property turns to visha<\/em> (poison) in contrast if visha<\/em> is prepared according to rules and regulation it can be used as in the form of medicine3. According to Acharya Charak, to treat any disease successfully, a physician should have genuine quality of drug in hand, not only this but also a physician becomes competent to cure all diseases only when he possesses the complete knowledge of all drugs including the principles of its manufacturing.<\/p>\n

The rule of potentiation of the drug action has been explained well by Charaka and\u00a0 Vagbhata. It is said that even a simple drug could be made in to most powerful one by simple procedures like addition or deletion of certain drugs, by keeping the drugs with certain bhavana dravyas<\/em> (triturating media) for a specific time, by collecting the drugs schedule period, by following certain modificatory procedures and by one\u2019s own intelligence.<\/p>\n

Charaka says that after proper processing even a poisonous or tikshana dravya<\/em> can converts in to excellent medicine. Ancient Ayurvedic scholars are very much rational and have strong scientific backgrounds in fundamentals principle, concerning with drug manufacturing.<\/p>\n

Ayurvedic doctrine tells, to treat a patient as a whole and not a disease alone. A substance (crude drug) becomes ausadha<\/em> (medicine) only when it is subjected to Kalpana<\/em> (manufacturing and presenting to proper dosage form). The nature of the drugs governs the dosage form to be prepared from it. Hence the drugs were prepared in different dosage forms due to several reasons.<\/p>\n

Shodhana<\/em><\/strong>4<\/strong>\u00a0(\u00bbPurification)<\/strong><\/p>\n

The literal meaning of the term \u2018shodhana\u2019<\/em> is purification. It is necessary to explain the exact implication of this term. Charaka has explained this term as \u2018Gunanteradhana<\/em>\u20195\u00a0(induction of the desired quality). During the process of sanskara\/shodhana<\/em>, the metals or mineral acquires a different property which is useful therapeutically and which overcomes original harmful effects of the metal. Shodhana\/Sanskara<\/em> have following objectives in view:<\/p>\n

Making hard material brittle.<\/p>\n

Elimination of associated\/adherent impurities.<\/p>\n

Conversion of some of the characteristics of drugs.<\/p>\n

Enhancement of drug efficacy.<\/p>\n

Minerals, metals, gems, calcium resources and certain animal and plant poisons etc. if used in human being without proper treatment, many toxic effects must be produced. Some times contamination takes place during storage, extraction and distribution and similarly during commercial transaction. Some extraneous or unwanted substances were added to them artificially by the greedy businessman, which produces toxic effects even in least quantity, therefore, in the era of pharmacovigilance serious car must be taken in steps to avoid adverse and toxic effect, even death.<\/p>\n

Bhavana6\u00a0(\u00bbLevigation)<\/strong><\/p>\n

In Bhavana, powdered substance is triturated with swarasa<\/em> (juice)\/kwatha<\/em> (decoction) of desired material in a khalva yantra<\/em> (mortar and pestle) until the material dries up. For this purpose, only that amount of liquid is added to make the whole substance and fill the container up to upper level of the substance. The main purpose of bhavana<\/em> is as follows:<\/p>\n

To disintegrate the material.<\/p>\n

To facilitate marana<\/em> (incineration) process.<\/p>\n

To enhance the properties of material.<\/p>\n

Marana7(\u00bbIncineration)<\/strong><\/p>\n

The term \u201cMarana\u2019 has been derived from the Sanskrit word Maryate, Nashyate, Bhasmikriyate,<\/em> which means killing, running or \/and covering into ashes. Metals, minerals, gems and jewels are added with drugs in various forms and then cooked to reduce them to the sate of fine powder in specially arranged cow dung cakes fire. These are non toxic and easily digestible as well assimilable. Marana<\/em> may have the following significances:<\/p>\n

To disintegrate the substance in to fine particles.<\/p>\n

To convert metals and minerals in to therapeutically useful form.<\/p>\n

To minimize\/remove their toxic effect.<\/p>\n

To enhance required qualities in drugs so as to make it enable for specific action in human body.<\/p>\n

To obtain stable dosage form of drugs.<\/p>\n

To convert the drugs in to palatable form.<\/p>\n

To make the material absorbable, adaptable and assimilable form.<\/p>\n

Amritikarana8\u00a0(\u00bb Nectarization)<\/strong><\/p>\n

Some poisonous metals do not give up their toxic effects completely even after shodhana<\/em> and marana<\/em>. They are further processed by adding more drugs till they become absolutely free from any toxic effect. This process is called Amritikarana<\/em> or inculcation of the properties of nectar to the drug. It potentates bhasma<\/em> qualities (Gunas) and induces colour loss (Varna hani)9. Amritikarana<\/em> is done after Marana as a precautionary measure10.<\/p>\n

Satvapatana11\u00a0(\u00bbExtraction of metal)<\/strong><\/p>\n

The drugs of mineral origin when mixed with alkaline, acidic and fusing materials and subjected to intense heating in specially designed furnace liberates their sara portion (metallic content) i.e. satva (essence) and the process is known as satvapatana. Satva is considered many fold more qualitative in comparison to bhasma of the particular raw material. Satva is used in mainly tow conditions:<\/p>\n

In mercurial preparation (Parada sankara and karma): In Rasa literature many satvas have their important role in mercurial processing.<\/p>\n

In therapeutics: Satavas are more effective in therapeutics like Abhraka satva in comparison to loha bhasma12. Also some where satava is administered to the patient where bahsma is contraindicated e.g. in pregnant lady loha bhasma is replaced by abhraka satva bhasma.<\/p>\n

Discussion<\/strong><\/p>\n

Ancient scholars were aware about the toxic qualities of minerals and metals. As such they cannot be used. If used they may produce many untoward effects. Safety and efficacy was the prime task before the ancient scholars and they were succeeded in this direction. Shodhana (indigenous purification procedure), Manara (indigenous incineration\/calcinations procedure), Samskara (specialized 8 fold of indigenous process used for mercury) etc. were developed. Plant materials are commonly used in mineral processing to convert them into different safe and effective doses forms. With the advent to these processing techniques metals and minerals became frequent in therapeutics. Further with the combination of plant and mineral products numerous formulations were derived.<\/p>\n

Conclusion<\/strong><\/p>\n

Rationality of pharmaceutical processes in Ayurveda is highly significant in various angles.<\/p>\n

By process of bhavana, material loosens the molecular cohesiveness which helps the metal to break into fine particles during the subsequent processing.<\/p>\n

The vegetable drugs which are used in the form of decoction or juice have their own therapeutic properties, imported and marana, the drug become non-toxic, easily digestible and absorbable, suitable for metabolic changes, assimmilable by tissue cells and become therapeutic potent.<\/p>\n

References<\/strong><\/p>\n

    \n
  1. Acharya Charaka, Charaka Samhita with Vidyotini Hindi Commentary by Acharya Kasinath Shastri and Gorakhnath Chaturvedi, Chaukhambha Bharati Academy, Varanasi, 16thedition, Sutra Sthana 1\/24 (1984).<\/li>\n
  2. Acharya Vagbhata, Astanga Hridaya with Hindi commentary by Dr. Brahmanada Tripathi, Chaukhambha Sanskrita Pratistthan, Varansi, reprint, Sutra Sthana 9\/10 (2005).<\/li>\n
  3. Acharya Charaka, Charaka Samhita with Vidyotini Hindi Commentary by Acharya Kasinath Shastri and Gorakhnath Chaturvedi, Chaukhambha Bharati Academy, Varansi, 16th\u00a0edition, Sutra Sthana 1\/27 (1989).<\/li>\n
  4. Vaidya Sadananda Sharma, Rasa Trangini with Sanskrit commentary by Pandit Haridatta Shastri, edited by Pandit Kasinath Shastri, Motilal Banarasidad, Delhi, 11thedition, Tarang 2\/52 (2004).<\/li>\n
  5. Acharya Charaka, Charaka Samhita with Vidyotini Hindi Commentary by Acharya Kasinath Shastri and Gorakhnath Chaturveid, Chaukhambha Bharati Academy, Varansi, 16thedition, Vimana Sthana 1\/21 (1989).<\/li>\n
  6. Vaidya Sadananta Sharma, Rasa Tarangini with Sanskrit Commentary by Pandit Haridatta Shastri, edited by Pandit Kasinath Shastri, Motilal Banarasidad, Delhi, Tarang 2\/49 (2004).<\/li>\n
  7. Vaidya Sadananda Sharma, Rasa Tarangini with Sanskrit commentary by Pandit Haridatta Shastri, edited by Pandit Kasinath Shastri, 11thedition Tarang 7\/1-2 (2004).<\/li>\n
  8. Viadya Sadanada Sharma, Rasa Tarangini with Sanskrit commentary by Pandit Haridatta Shastri, edited by Pandit Kasinath Shastri, Motilal Banarasidas, Delhi, 11thedition, Tarang 2\/58 (2004).<\/li>\n
  9. Sri Madhava Upadhyaya, Ayurveda Prakash with Hindi Commentary by Sri Gularaja Sharama, Bhaukhambha Bharati Academy, Varansi,Chap. 2\/135 (2007).<\/li>\n
  10. Vaidya Sadananda Sharma, Rasa Tarangini with Sanskrit commentary by Pandit Haridatta Shastri, edited by Pandit Kasinath Shastri, Motilal Banarasidas, Delhi, 11thedition, Tarang 17\/34 (2004).<\/li>\n
  11. Acharya Vagbhata, Rasa Ratna Samuchhaya with Rasaprada Hindi commentary by Dr. Indra Dev Tripahti, Chaukhambha Sanskrit Bhawan, Varansi, 2ndedition, Chap. 7\/34 (2003).<\/li>\n
  12. Sri Bhagwana Govind Padacharya, Rasa Haridaya Tantra with Mugdhabodhini Sanskrit Commentary by Achrya Chaturbhuja Mishra, Krishna Gopal Ayurveda Bhawan, Ajmer, 2ndedition, Avabodha 8\/19 (2002).<\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"

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