{"id":39195,"date":"2021-06-30T11:54:25","date_gmt":"2021-06-30T11:54:25","guid":{"rendered":"https:\/\/biomedpharmajournal.org\/?p=39195"},"modified":"2021-07-13T08:18:08","modified_gmt":"2021-07-13T08:18:08","slug":"optimization-of-the-functional-state-of-the-cardiovascular-system-in-women-with-a-complex-of-dosage-physical-exertion","status":"publish","type":"post","link":"https:\/\/biomedpharmajournal.org\/staging\/vol14no2\/optimization-of-the-functional-state-of-the-cardiovascular-system-in-women-with-a-complex-of-dosage-physical-exertion\/","title":{"rendered":"Optimization of the Functional State of the Cardiovascular System in Women with A Complex of Dosage Physical Exertion"},"content":{"rendered":"<p style=\"text-align: justify;\"><strong>Introduction<\/strong><\/p>\n<p style=\"text-align: justify;\">The progressive development of medical science and practice around the world has not yet been able to reduce the prevalence of arterial hypertension, which often complicates hypertensive crises<sup>1<\/sup>.\u00a0 Often, the development of a hypertensive crisis can lead to hemorrhagic strokes<sup>2<\/sup> with a deterioration in the general state of a person, to a disqualial persistence, and sometimes to death<sup>3<\/sup>. Women suffering from arterial hypertension are often very emotional, which leads to the formation of a tendency to hypertensive crises.\u00a0 The development of a hypertensive crisis, including middle-aged\u00a0women, has a very negative impact on their overall health level and reduces their overall working capacity<sup>4<\/sup>.\u00a0 The prevalence of hypertensive crises in women hypertensive is one of the incentives for the development of medical science<sup>5,6<\/sup>.\u00a0 Studies are conducted with the aim of improving the schemes for the use of drugs of vasculating effects<sup>7<\/sup>, as well as in relation to increasing the efficiency of rehabilitation, eliminating the effects of vascular spasms and preventing their occurrence later<sup>8<\/sup>.\u00a0 In this\u00a0 regard, regular physical exertion, promoting the optimization of their general emotional and physical condition and the resistant expansion of arterial and venous vessels, are presented<sup>9,10<\/sup>.<\/p>\n<p style=\"text-align: justify;\">Long-term observations make it possible to consider regular dosage physical exertion a very effective option for mass rehabilitation, strengthening the body as a whole<sup>11<\/sup>.\u00a0 In this regard, muscle spacecraft regular loads rightfully refer to very frequently used rehabilitation options for different categories of patients, primarily with vascular pathology<sup>12<\/sup>.\u00a0 Moderate activation of muscle work stimulates capillar closets, eliminating the phenomena of vessel spasms, weakens hypoxia in vital\u00a0organs, lowering the risk of developing vascular disasters due to the normalization of hemodynamics in various vascular regions and contributing to the general recovery of patients<sup>13,14<\/sup>.<\/p>\n<p style=\"text-align: justify;\">Of great importance for the resistant optimization of the general functional status of people with any vascular pathology has the provision of rational rehabilitation after a hypertonic crisis [15].\u00a0 It is possible to minimize the disorders that are available after the hypertensive crime and reduce the risk of repetition of the crisis situation<sup>16, 17<\/sup>.<\/p>\n<p style=\"text-align: justify;\">The purpose of the study is to evaluate the rehabilitation possibilities of the developed complex of physical exertion for women who are ill hypertension after a hypertonic crisis.<\/p>\n<p style=\"text-align: justify;\"><strong>Materials and Methods<\/strong><\/p>\n<p style=\"text-align: justify;\">It was approved by the local ethics committee of the Belgorod State National Research University (protocol \u211610 of\u00a0 2017.11.10).<\/p>\n<p style=\"text-align: justify;\">The study was conducted at 55 women 36-55 years, with the arterial hypertension of the second degree without the phenomena of heart failure, which moved about one month ago the hypertensive crisis of the first type.\u00a0 All women taken under observation on a permanent basis took an Enalapril to 10mg two times a day as hypotensive therapy.\u00a0 A random method of all patients were distributed into two comparable groups, called experimental 1 group and experimental 2 groups.\u00a0 Group 1 (26 people)\u00a0has passed the rehabilitation of the scheme traditionally used during the rehabilitation.\u00a0 She included daily facilitated studies of therapeutic physical culture, short training on simulators, the use of 10 hydromassage sessions.\u00a0 An experienced group 2 (29 people) has been rehabilitated by the authored scheme consisting of daily runs in free mode with a duration of at least 20 minutes a day during the first half of the day, rational breathing exercises and walking along the horizontal plane at an\u00a0accelerated pace daily at least 30 minutes\u00a0 after noon.\u00a0 In all cases, rehabilitation was carried out for two months.\u00a0 The control group consisted 23 clinically healthy women aged 36-60 years, surveyed once.\u00a0 Patients who entered both experienced groups were examined twice when taking into research and at the end of all health events.<\/p>\n<p style=\"text-align: justify;\">A number of indicators were registered for the study: the frequency of heart cuts, the respiratory rate, the value of blood pressure was determined.\u00a0 All women conducted a standard orthostatic sample (a rapid lift to the feet after a five-minute stay in the lying position) and the standard trial of RF (after horizontal position for 5 minutes).\u00a0 The surveyed recorded the pulse value in 15 seconds (P1) alone, after 30 squats in 45 seconds, after adopting a horizontal position, it was again\u00a0considered over the first 15 seconds (P2) and for the final 15 seconds for the first minute after load (P3). The data obtained during the measurement ensured the possibility of calculating the ruft index by applying the formula: (4 x (P1 + P2 + P3) &#8211; 200) \/ 10.<\/p>\n<p style=\"text-align: justify;\">A 6-minute walk test, which takes into account the amount of the distance, which is possible to pass in 6 minutes by a strictly horizontal plane with the highest speed, which is possible.\u00a0 According to this data, a conclusion was made on a person belonging to a specific functional class.\u00a0 The surveyed were counted for the first functional class when they could pass 425-550 meters.\u00a0 The surveyed\u00a0attributed to the second functional class in the event that they were able to pass 301-425 meters.\u00a0 The third functional class included persons passing 151-300 meters.\u00a0 The fourth functional class was women capable of passing within 6 minutes less than 150 meters.<\/p>\n<p style=\"text-align: justify;\">All results were processed statically by calculating the Student t-criterion.<\/p>\n<p style=\"text-align: justify;\"><strong>Results<\/strong><\/p>\n<p style=\"text-align: justify;\">The values \u200b\u200bestablished during the study are assembled in Table 1. At the beginning of the observation of statistically significant differences in all recorded indicators in women with the arterial hypertension of both experimental groups, there was no detected.<\/p>\n<p style=\"text-align: justify;\"><strong>Table 1: Results of research.<\/strong><\/p>\n<table style=\"width: 95%;\" border=\"1\" cellspacing=\"0\" cellpadding=\"4\">\n<tbody>\n<tr>\n<td style=\"text-align: center;\" rowspan=\"2\" width=\"135\"><strong>Indicators taken into account in the work<\/strong><\/td>\n<td style=\"text-align: center;\" colspan=\"2\" width=\"200\"><strong>Experimental group 1, <\/strong><\/p>\n<p><strong>M\u00b1m, n=26<\/strong><\/td>\n<td style=\"text-align: center;\" colspan=\"3\" width=\"221\"><strong>Experimental group 2,<\/strong><\/p>\n<p><strong>M\u00b1m, n=29<\/strong><\/td>\n<td style=\"text-align: center;\" rowspan=\"2\" width=\"118\"><strong>Control group,<\/strong><\/p>\n<p><strong>M\u00b1m,<\/strong><\/p>\n<p><strong>n=23<\/strong><\/td>\n<\/tr>\n<tr>\n<td style=\"text-align: center;\" width=\"100\"><strong>at the beginning of the study<\/strong><\/td>\n<td style=\"text-align: center;\" width=\"100\"><strong>at the end of the study<\/strong><\/td>\n<td style=\"text-align: center;\" width=\"100\"><strong>at the beginning of the study<\/strong><\/td>\n<td style=\"text-align: center;\" colspan=\"2\" width=\"121\"><strong>at the end of the study<\/strong><\/td>\n<\/tr>\n<tr>\n<td style=\"text-align: center;\" width=\"135\"><strong>Level of systolic blood pressure,<\/strong><\/p>\n<p><strong>mmHg.<\/strong><\/td>\n<td style=\"text-align: center;\" width=\"100\">164.3\u00b12.12<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/td>\n<td style=\"text-align: center;\" width=\"100\">142.8\u00b11.79<\/p>\n<p>\u0440&lt;0.05<\/p>\n<p>&nbsp;<\/td>\n<td style=\"text-align: center;\" width=\"100\">163.8\u00b12.06<\/td>\n<td style=\"text-align: center;\" colspan=\"2\" width=\"121\">122.6\u00b11.60<\/p>\n<p>\u0440&lt;0.01<\/p>\n<p>\u0440<sub>1<\/sub>&lt;0.05<\/td>\n<td style=\"text-align: center;\" width=\"118\">118.4\u00b10.83<\/td>\n<\/tr>\n<tr>\n<td style=\"text-align: center;\" width=\"135\"><strong>Level of diastolic blood pressure,<\/strong><\/p>\n<p><strong>mmHg.<\/strong><\/td>\n<td style=\"text-align: center;\" width=\"100\">105.6\u00b10.61<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/td>\n<td style=\"text-align: center;\" width=\"100\">94.5\u00b10.54<\/p>\n<p>\u0440&lt;0.05<\/p>\n<p>&nbsp;<\/td>\n<td style=\"text-align: center;\" width=\"100\">106.7\u00b10.57<\/td>\n<td style=\"text-align: center;\" colspan=\"2\" width=\"121\">80.8\u00b10.45<\/p>\n<p>\u0440&lt;0.01<\/p>\n<p>\u0440<sub>1<\/sub>&lt;0.05<\/td>\n<td style=\"text-align: center;\" width=\"118\">71.3\u00b10.32<\/td>\n<\/tr>\n<tr>\n<td style=\"text-align: center;\" width=\"135\"><strong>The number of cardiac abbreviations in 1 minute,<\/strong><\/p>\n<p><strong>strikes\/minute<\/strong><\/td>\n<td style=\"text-align: center;\" width=\"100\">92.8\u00b10.85<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/td>\n<td style=\"text-align: center;\" width=\"100\">82.3\u00b10.74<\/p>\n<p>\u0440&lt;0.05<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/td>\n<td style=\"text-align: center;\" width=\"100\">90.3\u00b10.72<\/td>\n<td style=\"text-align: center;\" colspan=\"2\" width=\"121\">69.0\u00b10.61<\/p>\n<p>\u0440&lt;0.01<\/p>\n<p>\u0440<sub>1<\/sub>&lt;0.05<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/td>\n<td style=\"text-align: center;\" width=\"118\">68.2\u00b10.96<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/td>\n<\/tr>\n<tr>\n<td style=\"text-align: center;\" width=\"135\"><strong>The number of respiratory movements in 1 minute,<\/strong><\/p>\n<p><strong>times\/minute<\/strong><\/td>\n<td style=\"text-align: center;\" width=\"100\">19.5\u00b10.27<\/td>\n<td style=\"text-align: center;\" width=\"100\">18.4\u00b10.38<\/p>\n<p>\u0440&lt;0.05<\/p>\n<p><strong>\u00a0<\/strong><\/td>\n<td style=\"text-align: center;\" width=\"100\">20.3\u00b10.29<\/td>\n<td style=\"text-align: center;\" colspan=\"2\" width=\"121\">16.8\u00b10.21<\/p>\n<p>\u0440&lt;0.01<\/p>\n<p>\u0440<sub>1<\/sub>&lt;0.05<\/td>\n<td style=\"text-align: center;\" width=\"118\">16.2\u00b10.34<\/td>\n<\/tr>\n<tr>\n<td style=\"text-align: center;\" width=\"135\"><strong>Orthostatic sample indicator, strikes \/ minute<\/strong><\/td>\n<td style=\"text-align: center;\" width=\"100\">24.3\u00b10.21<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/td>\n<td style=\"text-align: center;\" width=\"100\">19.5\u00b10.33<\/p>\n<p>\u0440&lt;0.05<\/p>\n<p>&nbsp;<\/td>\n<td style=\"text-align: center;\" width=\"100\">25.2\u00b10.36<\/td>\n<td style=\"text-align: center;\" colspan=\"2\" width=\"121\">15.3\u00b10.22<\/p>\n<p>\u0440&lt;0.01<\/p>\n<p>\u0440<sub>1<\/sub>&lt;0.05<\/td>\n<td style=\"text-align: center;\" width=\"118\">14.4\u00b10.30<\/td>\n<\/tr>\n<tr>\n<td style=\"text-align: center;\" width=\"135\"><strong>Value of the index Rufhe, points<\/strong><\/td>\n<td style=\"text-align: center;\" width=\"100\">12.8\u00b10.27<\/td>\n<td style=\"text-align: center;\" width=\"100\">9.1\u00b10.16<\/p>\n<p>\u0440&lt;0.01<\/td>\n<td style=\"text-align: center;\" width=\"100\">12.4\u00b10.32<\/td>\n<td style=\"text-align: center;\" colspan=\"2\" width=\"121\">5.0\u00b10.15<\/p>\n<p>\u0440&lt;0.01<\/p>\n<p>\u0440<sub>1<\/sub>&lt;0.01<\/td>\n<td style=\"text-align: center;\" width=\"118\">4.6\u00b10.16<\/td>\n<\/tr>\n<tr>\n<td style=\"text-align: center;\" width=\"135\"><strong>Distance in walking dough for 6 minutes,<\/strong><\/p>\n<p><strong>steps\/minute<\/strong><\/td>\n<td style=\"text-align: center;\" width=\"100\">319.0\u00b11.24<\/td>\n<td style=\"text-align: center;\" width=\"100\">357.9\u00b11.10<\/p>\n<p>\u0440&lt;0.05<\/td>\n<td style=\"text-align: center;\" colspan=\"2\" width=\"100\">302.4\u00b10.97<\/td>\n<td style=\"text-align: center;\" width=\"120\">472.6\u00b10.70<\/p>\n<p>\u0440&lt;0.01<\/p>\n<p>\u0440<sub>1<\/sub>&lt;0.01<\/td>\n<td style=\"text-align: center;\" width=\"118\">489.7\u00b11.18<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p style=\"text-align: justify;\">Note: p \u2013 \u00a0is the statistical differences of changes in the value of parameters during the observation, p<sub>1<\/sub>\u2013 is the statistical differences between the final observation results in both groups of patients.<\/p>\n<p style=\"text-align: justify;\">Evaluation of digital data in both observation groups After applying, their rehabilitation has made it possible to establish reliable differences between them in all charged indicators in favor of the author&#8217;s proof.<\/p>\n<p style=\"text-align: justify;\">Against the background of rehabilitation in the second experimental group of women suffering from arterial hypertension, the value of the frequency of heart cuts has dropped by 30.9%, leaving the level of the control group.\u00a0 In patients who had the first experienced group, this figure decreased by only 12.7%.\u00a0 In two experimental groups, the frequency of respiratory acts decreased, but it was more pronounced in patients of the second group (20.8%), providing them with their output of this indicator to the level of control.\u00a0 In women, the second experimental group, the levels of systolic and diastolic\u00a0blood pressure were normalized, decreased by 33.6% and by 32.0%, respectively.\u00a0 In women of the first experimental group, the effectiveness of rehabilitation for this indicator was lower.\u00a0 They retained an increased level of blood pressure.<\/p>\n<p style=\"text-align: justify;\">The results of the patients of the orthostatic sample after their rehabilitation have decreased: in a group of first by 24.6%, and in a group of second to 64.7% with the achievement of control values \u200b\u200bonly in the second case.\u00a0 As a result of the recovery activities, the Rufier index decreased, but reached the level of control only in women of the second group due to a decrease of 2.48 times (in women of the first group, its value was reduced by only 39.1%).<\/p>\n<p style=\"text-align: justify;\">The values \u200b\u200bfound during the sample with a 6-minute walking point indicated a greater efficiency of author&#8217;s physical rehabilitation.\u00a0 In the second experimental group, a more pronounced increase occurred, overcame in 6 minutes by 56.3%, while after applying the traditional scheme of physical rehabilitation, this indicator increased only by 11.9%.\u00a0 By the end of the observation, only in the experimental group 2 there was a correspondence of its value of the control level.<\/p>\n<p style=\"text-align: justify;\"><strong>Discussion<\/strong><\/p>\n<p style=\"text-align: justify;\">Hypertensive crisis often may occur in women suffering from arterial hypertension<sup>18<\/sup>.\u00a0 Under these conditions, hemodynamics are temporarily worsen in the entire body with the development of ischemia phenomena<sup>19<\/sup>.\u00a0 The decrease in the level of blood pressure eliminates the phenomena of ischemia and arising symptoms<sup>20<\/sup>.\u00a0 In this case, the general state is improved, but the high risk of repetition of a hypertensive crision is maintained, which can be complicated by thrombosis<sup>21<\/sup>.\u00a0 This makes a hypertonic crisis a very dangerous state, which needs to continue the improvement of physical rehabilitation options<sup>22<\/sup>.<\/p>\n<p style=\"text-align: justify;\">Due to the serious practical need to ensure high efficiency of the process of rehabilitation of patients with arterial hypertension after a hypertensive crisis, further research is underway to develop schemes for their recovery<sup>23,24<\/sup>.\u00a0 The authors were determined to determine the effectiveness of two improvement schemes for this vascular pathology.\u00a0 The normalization of the recorded indicators of the cardiovascular system of observed patients was marked in the second group, where the rehabilitation was carried out according to the author&#8217;s scheme.The effectiveness of the impact was determined by the dynamics in patients of the cardio-vascular system functions against the background of the correction of their general physical status<sup>25<\/sup>.<\/p>\n<p style=\"text-align: justify;\">The data obtained in the conducted study make it possible to assume that the tested rehabilitation complex, which includes physical stages in the form of jogging, respiratory exercises and active walk, is able to more pronounce the body of women who have undergone hypertensive crisis, strengthening their heart and optimizing the tone of their vessels<sup>26<\/sup>.\u00a0 It provided them to minimize the risk of repetition of a hypertensive crisis.\u00a0 A greater recovery achieved in the experimental group 2 is obviously due to a more complex positive effect on the body applied in these women&#8217;s motion engine activity<sup>27,28<\/sup>.\u00a0 It is clear that it is more intensifying the functioning of the heart, the brain and the bone-muscular apparatus<sup>29<\/sup>.\u00a0 The simultaneous use of components that made up the author&#8217;s rehabilitation\u00a0scheme ensured the achievement of a more pronounced optimization of the parameters taken into account due to the onset of mutualation of the effects of all elements of the healing scheme<sup>30,31<\/sup>.\u00a0 Undoubtedly, the greater efficiency of the author&#8217;s rehabilitation is caused by the simultaneous use of its elements that enhance the activities of the heart and vessels<sup>32,33<\/sup>.\u00a0 Apparently, the application of the components of the author&#8217;s scheme ensured in women hypertensive, optimally coached the muscular system and activated biosynthetic and metabolic processes in the organs<sup>34,35<\/sup>.\u00a0 Against the background of appointing the author&#8217;s scheme of physical rehabilitation, the heart muscle was more stimulated and the metabolism was normalized in it.\u00a0 In addition, there is reason to believe that against the background of the copyright of the rehabilitation scheme there was a more pronounced increase in the venous return to the heart, optimizing general hemodynamics<sup>36<\/sup>.<\/p>\n<p style=\"text-align: justify;\">The use of at the same time all components that have been tested by rehabilitation scheme optimized the overall state of patients, contributing to strengthening adaptation to a regular increase in muscle activity, which positively affected the blood parameters and hemostasis system<sup>37<\/sup>.\u00a0 Physiological changes in them lead to biologically advantageous morphological and functional changes in all organs and muscular system, increasing the reserves of the body<sup>38<\/sup>.\u00a0 Stimulation of aerobic mechanisms in the brain after a hypertensive crisis normalized the emotional background of patients.\u00a0 This stimulated the process of optimizing their physical characteristics, providing a quick transition to the usual way of life due to the accelerated entry of processes in the body into the status of the norm.<\/p>\n<p style=\"text-align: justify;\"><strong>Conclusion<\/strong><\/p>\n<p style=\"text-align: justify;\">Women hypertensive, having experienced hypertensive crisis, have obvious signs of asthenia system of heart and vessels.\u00a0 The use of the patient&#8217;s traditional rehabilitation in this category of traditional rehabilitation has an unbearable effect.\u00a0 The appointment of the author&#8217;s scheme of physical exertion in women hypertensive after a hypertensive crisis, which includes regular jogging, breathing exercises and walking hours at an accelerated pace, turned out to be very effective in optimizing the state of their cardiovascular system.\u00a0 The result resulting after the author&#8217;s rehabilitation scheme was formed to minimize the possibility of repetition of a hypertensive crisis and stimulated the existing functional reserves of the body of women suffering from arterial hypertension.<\/p>\n<p style=\"text-align: justify;\"><strong>Acknowledgement<\/strong><\/p>\n<p style=\"text-align: justify;\">The team of authors thanks the administration of the Belgorod State National Research University for the opportunity to conduct research on its basis.<\/p>\n<p style=\"text-align: justify;\"><strong>Conflict of Interest<\/strong><\/p>\n<p style=\"text-align: justify;\">No conflict of interest is declared.<\/p>\n<p style=\"text-align: justify;\"><strong>Sources of Financing<\/strong><\/p>\n<p style=\"text-align: justify;\">The study was conducted at the expense of the authors.<\/p>\n<p style=\"text-align: justify;\"><strong>References<\/strong><\/p>\n<ol>\n<li style=\"text-align: justify;\">Medvedev, I.N. 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Functional Features of Hemocoagulation in Rats with Experimentally Formed Arterial Hypertension in Conditions of Increased Motor Activity. <em>PrensaMedica Argentina<\/em>, 105(8) : 469-476.(2019)<br \/>\n<a href=\"https:\/\/doi.org\/10.47275\/0032-745X-102\" target=\"_blank\">CrossRef<\/a><\/li>\n<li style=\"text-align: justify;\">Vorobyeva, N.V., Khabibulina, T.V., Skripleva, E.V., Skoblikova, T.V., Zatsepin, V.I., Skriplev, A.V. Effect of Lipid-lowering Therapy and Regular Exercise on the Fibrinolytic System in Patients with Metabolic Syndrome. <em>Prensa Med Argent<\/em>, 105(1). DOI: 10.41720032-745X.1000327 (2019)<br \/>\n<a href=\"https:\/\/doi.org\/10.47275\/0032-745X-153\" target=\"_blank\">CrossRef<\/a><\/li>\n<li style=\"text-align: justify;\">Avaliani, V.M., Chernov, I.I., Shonbin, A.N. Coronary surgery for multifocal atherosclerosis. Moscow: Universum Publishing, 384. (2005)<\/li>\n<li style=\"text-align: justify;\">Medvedev, I.N. Dynamics of violations of intravascular platelet activity in rats during the formation of metabolic syndrome using fructose models. <em>Problems of nutrition<\/em>, 85(1):42-46. (2016)<\/li>\n<li style=\"text-align: justify;\">Tkacheva, E.S., Medvedev, I.N. Functional features of vascular hemostasis in piglets of milk and vegetable nutrition. IOP Conference Series: Earth and Environmental Science, 421 (2), 022041. doi:10.1088\/1755-1315\/421\/2\/022041 (2020)<br \/>\n<a href=\"https:\/\/doi.org\/10.1088\/1755-1315\/421\/2\/022041\" target=\"_blank\">CrossRef<\/a><\/li>\n<li style=\"text-align: justify;\">Medvedev, I.N. The Impact of Durable and Regular Training in Handto-hand Fighting Section on Aggregative Platelet Activity of Persons at the First Mature Age.<em>Annual Research &amp; Review in Biology<\/em>, 15(2): 1-6. DOI: 10.9734\/ARRB\/2017\/35048 (2017)<br \/>\n<a href=\"https:\/\/doi.org\/10.9734\/ARRB\/2017\/35048\" target=\"_blank\">CrossRef<\/a><\/li>\n<li style=\"text-align: justify;\">Mavrodiy, V. Cardiology. Main problems. Moscow, 8122. (2017)<\/li>\n<li style=\"text-align: justify;\">Karpov,V.Yu., Medvedev, I.N., Kazakov, D.A., Sibgatulina, F.R., Shulgin, A.M., Krasnov, R.B. Physiological Basis of Rehabilitation for Ulnar Neuritis. <em>Biomedical &amp; Pharmacology Journal<\/em>, 13(2) : 585-590. http:\/\/dx.doi.org\/10.13005\/bpj\/1921 (2020)<br \/>\n<a href=\"https:\/\/doi.org\/10.13005\/bpj\/1921\" target=\"_blank\">CrossRef<\/a><\/li>\n<li style=\"text-align: justify;\">Makhov, A.S., Medvedev, I.N. Functional state of junior footballers with asthenia after rehabilitation complex. <em>TeoriyaiPraktikaFizicheskoyKultury<\/em>, 2 : 10. (2019)<\/li>\n<li style=\"text-align: justify;\">Bokeria, L.A., Gudkova, R.G. Cardiovascular Surgery-15. Diseases and congenital malformations of the circulatory system.\u00a0 Moscow: Scientific Center for Cardiovascular Surgery named after\u00a0 N. Bakuleva of the Russian Academy of Medical Sciences, 212. (2016)<\/li>\n<li style=\"text-align: justify;\">Medvedev, I.N.Place and Possibilities of the Robotic System Lokomat in the Rehabilitation of Patients after Ischemic Stroke. <em>Biomedical &amp; Pharmacology Journal<\/em>, 12(1): 131-140. (2019)<br \/>\n<a href=\"https:\/\/doi.org\/10.13005\/bpj\/1621\" target=\"_blank\">CrossRef<\/a><\/li>\n<li style=\"text-align: justify;\">Medvedev, I.N., Gusev, A.V., Malyshev, A.V., Mikhailova, O.D., Garina, E.V., Petina,E.Sh., Tagirova,N.Dz. Influence of the Experience of Health-Improving Jogging on the Level of Functional Activity of Platelets in Men of the Second Mature Age. <em>Systematic Reviews in Pharmacy<\/em>, 11(8) : 432-438. (2020)<\/li>\n<li style=\"text-align: justify;\">Vorobyeva, N.V., Medvedev, I.N. Functional platelet activity in Dutch newborn calves. IOP Conference Series: Earth and Environmental Science,421(2), 022042. doi:10.1088\/1755-1315\/421\/2\/022042 (2020)<br \/>\n<a href=\"https:\/\/doi.org\/10.1088\/1755-1315\/421\/2\/022042\" target=\"_blank\">CrossRef<\/a><\/li>\n<li style=\"text-align: justify;\">Makhov, A.S., Medvedev, I.N., Mikhailova, I.V., Alifirov, A.I. Psychological satisfaction of parents of young football players with a mosaic form of down syndrome by the quality of sports training. <em>PrensaMedica Argentina<\/em>, 105(8) : 477-482. (2019)<br \/>\n<a href=\"https:\/\/doi.org\/10.47275\/0032-745X-103\" target=\"_blank\">CrossRef<\/a><\/li>\n<li style=\"text-align: justify;\">Karpov,V.Yu., Medvedev, I.N., Boldov, A.S., Sibgatulina, F.R., Fedorova, T.Y. Physiological Basis for the Use of Physical Activity in Conditions of Disorders of Carbohydrate and Lipid Metabolism. <em>Indian Journal of Public Health Research &amp; Development<\/em>, 10(8) :1899-1903. (2019)<br \/>\n<a href=\"https:\/\/doi.org\/10.5958\/0976-5506.2019.02128.4\" target=\"_blank\">CrossRef<\/a><\/li>\n<li style=\"text-align: justify;\">Karpov,V.Yu., Medvedev, I.N., Komarov, M.N., Lapina, N.M., Sharagin, V.I. Physical Rehabilitation of Adolescents with Bronchial Asthma. <em>Indian Journal of Public Health Research &amp; Development<\/em>, 10(8) :1910-1914.(2019)<br \/>\n<a href=\"https:\/\/doi.org\/10.5958\/0976-5506.2019.02130.2\" target=\"_blank\">CrossRef<\/a><\/li>\n<li style=\"text-align: justify;\">Medvedev IN, KarpovVYu, Batrakova IA, Dorontsev AV, Skorosov KK, Rysakova OG. Physiologically Significant Rehabilitation Measures for Acute Respiratory Viral Infection. <em>Biomedical &amp; Pharmacology Journal<\/em>, 13(2): 537-542. http:\/\/dx.doi.org\/10.13005\/bpj\/1915 (2020)<br \/>\n<a href=\"https:\/\/doi.org\/10.13005\/bpj\/1915\" target=\"_blank\">CrossRef<\/a><\/li>\n<li style=\"text-align: justify;\">Medvedev, I.N. Physiological response of the morphological characteristics of mammalian blood to the intake of selenium preparations into the body. IOP Conf. Series: Earth and Environmental Science. \u00a0IV International Scientific Conference: AGRITECH-IV-2020: Agribusiness, Environmental Engineering and Biotechnologies, 677 (4), 042060. (2021)<br \/>\n<a href=\"https:\/\/doi.org\/10.1088\/1755-1315\/677\/4\/042060\" target=\"_blank\">CrossRef<\/a><\/li>\n<li style=\"text-align: justify;\">Medvedev, I.N., Skoryatina, I.A. Pravastatin in correction of vessel wall antiplatelet control over the blood cells in patients with arterial hypertension and dyslipidemia.<em>Cardiovascular therapy and prevention<\/em>, 13(6):18-22. (2014)<br \/>\n<a href=\"https:\/\/doi.org\/10.15829\/1728-8800-2014-6-18-22\" target=\"_blank\">CrossRef<\/a><\/li>\n<li style=\"text-align: justify;\">Makhov, A.S., Medvedev, I.N. Role of coach in selection of exercises for athletes with disabilities based on physiological characteristics. <em>TeoriyaiPraktikaFizicheskoyKultury<\/em>,8 : 62. (2019)<br \/>\n<a href=\"https:\/\/doi.org\/10.15562\/bmj.v8i2.1097\" target=\"_blank\">CrossRef<\/a><\/li>\n<li style=\"text-align: justify;\">Vorobyeva, N.V., Medvedev, I.N. Functional activity of platelets in new-born calves of black-marked breed. <em>Bulgarian Journal of Agricultural Science<\/em>, 25(3) :570-574. (2019)<\/li>\n<li style=\"text-align: justify;\">Medvedev, I.N., Skoriatina, I.A. Effect of lovastatin on adhesive and aggregation function of platelets in patients with arterial hypertension and dyslipidemia. <em>Klinicheskaiameditsina<\/em>, 88(2) :38-40. (2010)<\/li>\n<li style=\"text-align: justify;\">Tkacheva, E.S., Medvedev, I.N. Physiological and biochemical status of newborn piglets. IOP Conference Series: Earth and Environmental Science,\u00a0Innovative Development of Agri-Food Technology. 548(8), 082090. https:\/\/iopscience.iop.org\/ article\/ 10.1088\/1755-1315\/548\/8\/082090(2020)<br \/>\n<a href=\"https:\/\/doi.org\/10.1088\/1755-1315\/548\/8\/082090\" target=\"_blank\">CrossRef<\/a><\/li>\n<li style=\"text-align: justify;\">Simonenko, V.B., Medvedev, I.N., Gamolina, O.V. Primary hemostasis activity in patients with arterial hypertension and impaired glucose tolerance treated with trandolapril.<em>Klinicheskaiameditsina<\/em>,89(2) :29-31. (2011)<\/li>\n<li style=\"text-align: justify;\">Medvedev, I.N., Plotnikov, A.V., Kumova, T.A. Rapid normalization of platelet hemostasis in patients with arterial hypertension and metabolic syndrome.<em>Russian Journal of Cardiology<\/em><em>,<\/em>2 :43-46. (2008)<\/li>\n<li style=\"text-align: justify;\">Makhov, A.S., Medvedev, I.N. Physiological and morphological peculiarities of children with Down\u2019s syndrome: A brief review. <em>Bali Medical Journal<\/em>, 9(1) :51-54. DOI:10.15562\/bmj.v9i1.1099 (2020)<br \/>\n<a href=\"https:\/\/doi.org\/10.15562\/bmj.v9i1.1099\" target=\"_blank\">CrossRef<\/a><\/li>\n<li style=\"text-align: justify;\">Amelina, I.V., Medvedev, I.N. Transcriptional activity of chromosome nucleolar organizing regions in population of Kursk region. <em>Bulletin of Experimental Biology and Medicine<\/em>, 147(6) : 730-732. (2009)<br \/>\n<a href=\"https:\/\/doi.org\/10.1007\/s10517-009-0592-1\" target=\"_blank\">CrossRef<\/a><\/li>\n<li style=\"text-align: justify;\">Mal, G.S.,\u00a0Makhova, A.V.,\u00a0Makurina, O.N., Tkacheva, E.S. Physiological changes in the body of young cattle when the feed additive &#8220;Bacitox&#8221; is introduced into their diet. IOP Conf. Series: Earth and Environmental Science. \u00a0IV International Scientific Conference: AGRITECH-IV-2020: Agribusiness, Environmental Engineering and Biotechnologies,677(4), 042067. (2021)<br \/>\n<a href=\"https:\/\/doi.org\/10.1088\/1755-1315\/677\/4\/042067\" target=\"_blank\">CrossRef<\/a><\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"<p>Introduction The progressive development of medical science and practice around  [&#8230;]<\/p>\n","protected":false},"author":14,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[92],"tags":[],"class_list":["post-39195","post","type-post","status-publish","format-standard","hentry","category-vol14no2"],"_links":{"self":[{"href":"https:\/\/biomedpharmajournal.org\/staging\/wp-json\/wp\/v2\/posts\/39195","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/biomedpharmajournal.org\/staging\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/biomedpharmajournal.org\/staging\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/biomedpharmajournal.org\/staging\/wp-json\/wp\/v2\/users\/14"}],"replies":[{"embeddable":true,"href":"https:\/\/biomedpharmajournal.org\/staging\/wp-json\/wp\/v2\/comments?post=39195"}],"version-history":[{"count":5,"href":"https:\/\/biomedpharmajournal.org\/staging\/wp-json\/wp\/v2\/posts\/39195\/revisions"}],"predecessor-version":[{"id":39831,"href":"https:\/\/biomedpharmajournal.org\/staging\/wp-json\/wp\/v2\/posts\/39195\/revisions\/39831"}],"wp:attachment":[{"href":"https:\/\/biomedpharmajournal.org\/staging\/wp-json\/wp\/v2\/media?parent=39195"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/biomedpharmajournal.org\/staging\/wp-json\/wp\/v2\/categories?post=39195"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/biomedpharmajournal.org\/staging\/wp-json\/wp\/v2\/tags?post=39195"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}