{"id":3863,"date":"2015-12-28T10:12:49","date_gmt":"2015-12-28T10:12:49","guid":{"rendered":"http:\/\/biomedpharmajournal.org\/?p=3863"},"modified":"2020-04-25T06:03:53","modified_gmt":"2020-04-25T06:03:53","slug":"study-of-non-tumoral-skin-lesions-among-patients-who-visited-imam-khomeini-hospital-pathology-clinic","status":"publish","type":"post","link":"https:\/\/biomedpharmajournal.org\/staging\/vol8no2\/study-of-non-tumoral-skin-lesions-among-patients-who-visited-imam-khomeini-hospital-pathology-clinic\/","title":{"rendered":"Study of Non-Tumoral Skin Lesions (Among Patients who visited Imam Khomeini Hospital Pathology Clinic)"},"content":{"rendered":"

Introduction<\/strong><\/p>\n

Non-tumoral skin lesions include several lesions such as eczema, hives, Psoriasis and Lichen-Planus.<\/p>\n

Eczema is a chronic allergic skin disease. This skin disease is usually seen in head, face, neck, elbow or knee. The disease can start when you are one month or one year old. The disease will ease when you are three but can toll again at any age. Different kinds of eczema include: Atopic Eczema, which is seen in people prone to allergy and especially among infants; Discoid Eczema, is characterized by round spots of oozing or dry rash, with clear boundaries, often on lower legs. The cause is unknown, and the condition tends to happen to adults; Contact eczema or dermatitis, resulting from direct reaction to a detergent, the symptoms includes<\/p>\n

Intense itching in the infected area, small blisters in the infected area that usually is<\/p>\n

Followed by releasing some liquid from the wound, skin thickening and dandruff due to the chronic swelling (12).<\/p>\n

Liechen-planus is a chronic inflammatory idiopathic disease than engages both skin and Mucous membrane. \u00a0This is a both acute and chronic disease with unknown cause and resistant toward cure. Many studies have shown a relation between the disease and Helicobacter pylori infection, though some other studies have rejected the relation (108).<\/p>\n

Hives are acute or chronic allergic reactions that appear as small pink spots or even sometimes as blisters along with intense itching. Hives usually happen due the reaction of our body toward Histamines or Histamine-like combinations. Among the triggers of hives we can name nuts, chocolates, fish, tomatoes, eggs, strawberries, milk, food essence, and fresh fruits especially citrus and drugs such as antibiotics as Penicillin, pain killers, Codeine, Indomethacin, sleeping pills, Vitamins and almost any other drugs. Continuous usage of Aspirin can also cause hives (11).<\/p>\n

Psoriasis is a self-immune chronic skin disease. The problem happens when the immune system of the body sends some false signals and the signals make the skin cells grow faster; one the symptoms of the disease is nail engagement in various kinds (7, 9).<\/p>\n

Studying non-tumoral skin lesions among the visiting patients in Imam Khomeini Hospital<\/strong><\/p>\n

Pathology Clinic during 2004 to 2012<\/strong><\/p>\n

Hypothesis<\/strong><\/p>\n

Erythematosus \\ Makulopapular \\ Squamous Cell Carcinoma (SCC) are among most common skin disease.<\/p>\n

Vesiculobullous, Vesicles and Pustules are among most common skin diseases. Skin Pigmentation Disorder is less epidemic among patients.<\/p>\n

Subcutaneous fat inflammatory diseases are not common among the patients.<\/p>\n

Bottom is most common area for the diseases.<\/p>\n

Research methodology<\/strong><\/p>\n

This is a descriptive-analytic periodical study.<\/p>\n

Research location<\/strong><\/p>\n

The chosen location is Imam Khomeini Hospital\u00a0Pathology Clinic.<\/p>\n

Population and sample size<\/strong><\/p>\n

The population includes patients who suffered skin diseases and visited Imam Khomeini Hospital Pathology Clinic during 2004-2012.<\/p>\n

In this study the patients are studied respectively as they visited the clinic.<\/p>\n

Data collection methodology<\/strong><\/p>\n

In this study we first chose all the patients who underwent biopsy in the past 9 years in Imam Khomeini Hospital Clinic. And then exclude all the patients with tumoral lesions. Next, we extracted the data from the patients\u2019 medical files (including age, gender and disease) and inserted it to the analyzing software.<\/p>\n

The Variables<\/strong><\/p>\n

 <\/p>\n\n\n\n
\"Table<\/td>\nTable 1<\/strong><\/p>\n

Click here to View\u00a0table<\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/p>\n

The Patients \u00a0Genders<\/strong><\/p>\n

In this study we analyzed the medical files for 866 patients suffering skin lesions. The results showed that among them 452 (52.19 percent) were women (Graph 1).<\/p>\n\n\n\n
\"Figure<\/td>\nFigure 1: Relative frequency of the participants based on gender<\/strong><\/p>\n

\u00a0Click here to View figure<\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/p>\n

Patients Age<\/strong><\/p>\n

The age of the patients were also studied. \u00a0The data analysis showed that the medium of the patient\u2019s age is between \u00b116.81 and 38.4. Also most of the patients were between 30 to 40 years old (Graph 2).<\/p>\n\n\n\n
\"Figure<\/td>\nFigure 2: Population frequency based on age<\/strong><\/p>\n

Click here to View figure<\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/p>\n

The Infected Area<\/strong><\/p>\n

The location of the lesion has also been studied. The analysis showed that bottom with 211 cases (24.36 percent) has been the most common area (Graph 3).<\/p>\n\n\n\n
\"Figure<\/td>\nFigure 3: Population frequency based on infected area<\/strong><\/p>\n

Click here to View figure<\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/p>\n

The patients visiting time<\/strong><\/p>\n

The year when the patients had visited the clinic was also studied. The analysis showed that in 2012 with 181 patients (20.90 percent) the Pathology clinic was most visited (Graph 4).<\/p>\n\n\n\n
\"Figure<\/td>\nFigure 4: Population frequency based on the visiting time<\/strong><\/p>\n

Click here to View figure<\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/p>\n

Non-infectious diseases of Erythematosus \\ Makulopapular \\ Squamous Cell<\/strong><\/p>\n

Carcinoma (SCC)<\/strong><\/p>\n

The \u00a0study \u00a0also \u00a0included\u00a0 Erythematosus \u00a0\\ \u00a0Makulopapular \u00a0\\ \u00a0Squamous\u00a0 Cell Carcinoma (SCC) diseases. The results showed that 325 patients (37.52 percent) were categorized in this set, among which Liechen-Planus with 153 cases (17.55 percent) was the most common disease (Graph 5).<\/p>\n\n\n\n
\"Figure<\/td>\nFigure 5: Population frequency based on non-infectious Erythematosus \\ Makulopapular \\ Squamous Cell Carcinoma (SCC) diseases<\/strong><\/p>\n

Click here to View figure<\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/p>\n

Skin – Vascular diseases<\/strong><\/p>\n

The study examined the diseases with vascular causes and it was proved that 41 patients (4.75 percent) suffered skin lesions with vascular causes, among which leukocytoclasis Vasculitis with 21 cases (2.42 percent) was the most common disease (Graph 6).<\/p>\n\n\n\n
\"Figure<\/td>\nFigure 6: Population frequency based on skin\u00a0\u00a0 \u00a0vascular diseases<\/strong><\/p>\n

Click here to View figure<\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/p>\n

Non-infectious Vesiculobullous, Vesicles and Pustules diseases<\/strong><\/p>\n

This group included 226 patients (26. 09 percent). In this group we can name Dermatitis Eczematous, Pemphigus, Pemphigoid, Vesiculobullous dermatitis (dermatitis herpetiformis) and \u00a0Vesicles- \u00a0Pustules\u00a0 dermatitis \u00a0(Erythema Multiforme), among which Eczema with 159 case was the most common disease (Graph 7).<\/p>\n\n\n\n
\"Figure<\/td>\nFigure 7: Population frequency based on non-infectious Vesiculobullous, Vesicles and Pustules diseases<\/strong><\/p>\n

Click here to View figure<\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/p>\n

Eczema (Dermatitis)<\/strong><\/p>\n

Since the diseases categorized under eczema title seem important and with high frequency, in this study we also analyzed the disease and found out Eczematoid dermatitis to be the most common (Graph 8).<\/p>\n\n\n\n
\"Population<\/td>\nFigure 8: Population frequency based on Eczema<\/strong><\/p>\n

Click here to View figure<\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/p>\n

Connective tissue diseases<\/strong><\/p>\n

After we examined the biopsy of the patients with Connective tissue disease, which included 145 patients (16.7 percent), we found out that the most common kind was chronic cutaneous lupus Erythematosus (DLE) with 87 patients (Graph 9).<\/p>\n\n\n\n
\"Figure<\/td>\nFigure 9: Population frequency based on connective tissue disease<\/strong><\/p>\n

Click here to View figure<\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/p>\n

Epidermal inflammatory diseases<\/strong><\/p>\n

In this study we also analyzed epidermal inflammatory diseases and the result showed that among 54 patients (6.23 percent), Pilaris keratosis was the most common (Graph 10).<\/p>\n\n\n\n
\"Figure<\/td>\nFigure 10: Population frequency based on epidermal inflammatory diseases.<\/strong><\/p>\n

Click here to View figure<\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/p>\n

Inflammatory lipid sub transcutaneous diseases<\/strong><\/p>\n

After the data was analyzed we found out that 16 patients (1.84 percent) were suffering inflammatory lipid sub transcutaneous diseases (Graph 11).<\/p>\n\n\n\n
\"Figure<\/td>\nFigure 11: Population frequency based on inflammatory lipid sub transcutaneous diseases<\/strong><\/p>\n

Click here to View figure<\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/p>\n

Skin Pigmentation diseases<\/strong><\/p>\n

Skin Pigmentation includes Vitiligo and hyperpigmentation after inflammation; the result of the analysis showed that 16 patients (1.84 percent) were suffering the disease (Graph 12).<\/p>\n\n\n\n
\"Figure<\/td>\nFigure 12: Population frequency based on skin Pigmentation diseases<\/strong><\/p>\n

Click here to View figure<\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/p>\n

Other Disease Groups<\/strong><\/p>\n

The other groups of the patients suffered from Histiocytosis (Cerebrotendinous), Skin toxicity caused by drugs, non-infectious Granulomatous (Granuloma Annulare), Degenerative disorder (solar Elastose), metabolic skin diseases (lichen amyloidosis) and physical disorders. The data analysis revealed that 43 patients (4.96 percent) were categorized in this group (Graph 13).<\/p>\n\n\n\n
\"Figure<\/td>\nFigure 13: Population frequency based on other group diseases<\/strong><\/p>\n

Click here to View figure<\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/p>\n

The Relation Between Age and Skin Pathology<\/strong><\/p>\n

In this study we analyzed patients with common pathology and skin diseases based on age. The results showed that there is no correlation between patients \u00a0ages and skin \u00a0pathology \u00a0(p=0.446). \u00a0The \u00a0data \u00a0analysis \u00a0was \u00a0implemented \u00a0using \u00a0ANOVA<\/p>\n

(Table 1-4).<\/p>\n\n\n\n
\"Table<\/td>\nTable 2<\/strong><\/p>\n

Click here to View\u00a0table<\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/p>\n

The relation between gender and skin pathology<\/strong><\/p>\n

After we analyzed the data using Chi-Square test we found no meaningful correlation between patients \u00a0gender and their skin diseases (p=0.247) (Table 2-4).<\/p>\n

 <\/p>\n\n\n\n
\"Table<\/td>\nTable 2-4: The correlation between patients \u00a0gender and skin pathology<\/strong><\/p>\n

Click here to View\u00a0table<\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/p>\n

The Debate<\/strong><\/p>\n

In this study we analyzed 866 patients with skin lesion diseases, out of which<\/p>\n

52.19 percent were women and their medium age was 38.47\u00b116.81 years. Bottom with 24.36 percent was the most common infected area. In this study also 37.52 percent of all the lesions were non-infectious Erythematosus \\ Makulopapular \\ Squamous Cell Carcinoma (SCC) diseases, among which Liechen-Planus (17.66 percent in total and 47.07 percent in the group) was the most common. About<\/p>\n

26.09 percent of the skin lesions were comprised of non-infectious Vesiculobullous, Vesicles and Pustules diseases, among which Eczema (18.36 percent in total and 70.35 percent in the group) was the most common. Moreover,<\/p>\n

16.7 percent of the skin lesions were recorded to be connective tissue diseases with DLE being the most common one (10.04 percent in total and 60 percent in the group). This is while, 6.23 percent of the skin lesions were epidermal inflammatory diseases with Pilaris keratosis being the most common disorder (2.77 percent in total and 44.44 percent in the group). Almost 1.84 percent of all the skin lesions were inflammatory lipid sub transcutaneous diseases with Erythema-Nodosum being the most common (1.83 percent in total and 75 percent in the group). On the other hand, 1.84 percent of the skin lesions were skin Pigmentation diseases with hyperpigmentation being the most common (1.61 percent in total and 87.5 percent in the group). And finally, 4.96 percent were related to the other groups among which Granuloma Annulare was the most common (1.96 percent in total and 39.53 percent in the group).<\/p>\n

Significantly, the data analysis showed that there is no correlation between the patients age and skin pathology (p=0.446) nor their gender (p=0.247).<\/p>\n

This is while, Tusi et al (5) in their study on over 450 patients, who were the personnel of a hospital, found that 44 percent of the studied population suffered Contact Dermatitis.<\/p>\n

Conclusion<\/strong><\/p>\n

This study showed that Eczema from non-infectious Vesiculobullous, Vesicles and Pustules diseases and Liechen-Planus from Erythematosus \\ Makulopapular \\ Squamous Cell Carcinoma (SCC) diseases were the most common non-tumoral skin lesions that have undergone biopsy.<\/p>\n

In this study we found that patients with Hives or Eczema visit Clinics less and their disease is usually cured through explanation and self-cure rather than biopsy.<\/p>\n

Bottom proved to be the most common infected area in the patients.<\/p>\n

Reference<\/strong><\/p>\n

    \n
  1. Saeed, Sadia, Connie A. Keehn, and Michael B. Morgan. “Cutaneous metastasis: a clinical, pathological, and immunohistochemical appraisal.” Journal of cutaneous pathology<\/em>6 (2004): 419-430.<\/li>\n
  2. B\u00e9net, Claire, et al. “Histologic and immunohistologic characterization of skin localization of myeloid disorders a study of 173 cases.” American journal of clinical pathology<\/em>2 (2011): 278-290.<\/li>\n
  3. Tani\u00e8re, Ph, et al. “Lymphomatoid granulomatosis–a report on four cases: evidence for B phenotype of the tumoral cells.” European Respiratory Journal<\/em>1 (1998): 102-106.<\/li>\n
  4. Bittencourt, Achil\u00e9a L., et al. “Adult T-Cell Leukemia\/Lymphoma in Bahia, Brazil Analysis of Prognostic Factors in a Group of 70 Patients.” American journal of clinical pathology<\/em>5 (2007): 875-882.<\/li>\n
  5. Rush, Walter L., et al. “Pulmonary pathology of Erdheim-Chester disease.” Modern Pathology<\/em>7 (2000): 747-754.<\/li>\n
  6. Topaz, Orit, et al. “Absence of intraepidermal glycosyltransferase ppGalNac-T3 expression in familial tumoral calcinosis.” The American journal of dermatopathology<\/em>3 (2005): 211-215.<\/li>\n
  7. Topaz, Orit, et al. “Mutations in GALNT3, encoding a protein involved in O-linked glycosylation, cause familial tumoral calcinosis.” Nature genetics<\/em>6 (2004): 579-581.<\/li>\n
  8. Perrin, C., et al. “Multicentric Reticulohistiocytosis: Immunohistological and Ultrastructural Study: A Pathology of Dendritic Cell Lineage.” The American journal of dermatopathology<\/em>5 (1992): 418-425.<\/li>\n
  9. Haroche, Julien, et al. “Dramatic efficacy of vemurafenib in both multisystemic and refractory Erdheim-Chester disease and Langerhans cell histiocytosis harboring the BRAF V600E mutation.” Blood<\/em>9 (2013): 1495-1500.<\/li>\n
  10. Ruiter, Dirk J., et al. “Pathologic staging of melanoma.” Seminars in oncology<\/em>. Vol. 29. No. 4. WB Saunders, 2002.<\/li>\n
  11. Bonnier, Pascal, et al. “Inflammatory carcinomas of the breast: a clinical, pathological, or a clinical and pathological definition?.” International journal of cancer<\/em>4 (1995): 382-385.<\/li>\n
  12. Ingen-Housz-Oro, Saskia, et al. “IgG4-related skin disease successfully treated by thalidomide: a report of 2 cases with emphasis on pathological aspects.” JAMA dermatology<\/em>6 (2013): 742-747.<\/li>\n
  13. Seeger, Leanne L., et al. “Tumoral calcinosis-like lesion of the proximal linea aspera.” Skeletal radiology<\/em>8 (1990): 579-583.<\/li>\n
  14. Hammoud, Sommer, Edward F. McCarthy, and Kristy Weber. “Tumoral calcinosis in infants: a report of three cases and review of the literature.” Clinical orthopaedics and related research<\/em> 436 (2005): 261-264.<\/li>\n
  15. Chojniak, Rubens, et al. “Computed tomography guided needle biopsy: experience from 1,300 procedures.” Sao Paulo Medical Journal<\/em> 124.1 (2006): 10-14.<\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"

    Introduction Non-tumoral skin lesions include several lesions such as eczema, […]<\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[],"class_list":["post-3863","post","type-post","status-publish","format-standard","hentry","category-vol8no2"],"_links":{"self":[{"href":"https:\/\/biomedpharmajournal.org\/staging\/wp-json\/wp\/v2\/posts\/3863","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/biomedpharmajournal.org\/staging\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/biomedpharmajournal.org\/staging\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/biomedpharmajournal.org\/staging\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/biomedpharmajournal.org\/staging\/wp-json\/wp\/v2\/comments?post=3863"}],"version-history":[{"count":5,"href":"https:\/\/biomedpharmajournal.org\/staging\/wp-json\/wp\/v2\/posts\/3863\/revisions"}],"predecessor-version":[{"id":32899,"href":"https:\/\/biomedpharmajournal.org\/staging\/wp-json\/wp\/v2\/posts\/3863\/revisions\/32899"}],"wp:attachment":[{"href":"https:\/\/biomedpharmajournal.org\/staging\/wp-json\/wp\/v2\/media?parent=3863"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/biomedpharmajournal.org\/staging\/wp-json\/wp\/v2\/categories?post=3863"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/biomedpharmajournal.org\/staging\/wp-json\/wp\/v2\/tags?post=3863"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}