{"id":29332,"date":"2019-12-28T11:26:37","date_gmt":"2019-12-28T11:26:37","guid":{"rendered":"http:\/\/biomedpharmajournal.org\/?p=29332"},"modified":"2020-04-22T05:39:42","modified_gmt":"2020-04-22T05:39:42","slug":"afatinib-associated-papulopustular-phototoxic-eruptions-a-novel-case-report","status":"publish","type":"post","link":"https:\/\/biomedpharmajournal.org\/staging\/vol12no4\/afatinib-associated-papulopustular-phototoxic-eruptions-a-novel-case-report\/","title":{"rendered":"Afatinib Associated Papulopustular Phototoxic Eruptions-  A Novel Case Report"},"content":{"rendered":"<p><strong>Introduction<\/strong><\/p>\n<p>Non Small Cell Lung Cancer(NSCLC) is the most common type of Lung Cancer, accounting for 85 % of all cases of lung Cancer<sup>[1]<\/sup>. NSCLC is characterized by multiple mutations, most commonly the EGFR -Epidermal Growth Factor Receptor mutation, followed by missense mutation of KRAS ( Kirsten Rat Sarcoma ) gene and ALK ( Anaplastic Lymphoma Receptor Kinase )gene mutations. Afatinib is an irreversible, multi-receptor inhibitor used in patients with Non-Small Cell Lung Cancer, who demonstrate EGFR mutations consisting of exon 19 deletion or exon 21 substitution<sup>[2]<\/sup>.<\/p>\n<p>Various side effects and complications have been associated with Afatinib use namely Vomiting, Diarrhoea , Fatigue, loss of appetite and Skin rash<sup>[3]<\/sup>. Cutaneous toxicity is the second most commonly reported side effect of the drug, the first being chronic diarrhoea<sup>[4]<\/sup>. A case of Drug induced fatal Pneumonitis has also been reported following First Generation EGFR-TKI Inhibitors<sup>[5]<\/sup>. Here we present a\u00a0 case\u00a0 of a 70 year old male, with inoperable Non-Small Cell Lung Carcinoma, started on Afatinib, who developed multiple raised skin lesions over the face , neck and the upper chest , following start of Afatinib.<\/p>\n<p><strong>Case Report<\/strong><\/p>\n<p>A 70 year old man, diagnosed with Stage IV Non-Small Cell-Adenocarcinoma of Lung with Broncho-Alveolar pattern. PET-CT whole Body showed a lesion of size 5.5*6.5*5.4 cm in the right middle lobe along with enlarged Sub- Carinal, Posterior Diaphragmatic and Right Inguinal Lymph Nodes. Genetic analysis showed medgenome Exon 20 Mutation. Patient was started on Tablet Afatinib 400mg OD for 15 days, following which patient developed multiple crusted papules and pustules over the face, involving the fo<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Introduction Non Small Cell Lung Cancer(NSCLC) is the most common  [&#8230;]<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[73],"tags":[],"class_list":["post-29332","post","type-post","status-publish","format-standard","hentry","category-vol12no4"],"_links":{"self":[{"href":"https:\/\/biomedpharmajournal.org\/staging\/wp-json\/wp\/v2\/posts\/29332","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/biomedpharmajournal.org\/staging\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/biomedpharmajournal.org\/staging\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/biomedpharmajournal.org\/staging\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/biomedpharmajournal.org\/staging\/wp-json\/wp\/v2\/comments?post=29332"}],"version-history":[{"count":6,"href":"https:\/\/biomedpharmajournal.org\/staging\/wp-json\/wp\/v2\/posts\/29332\/revisions"}],"predecessor-version":[{"id":31803,"href":"https:\/\/biomedpharmajournal.org\/staging\/wp-json\/wp\/v2\/posts\/29332\/revisions\/31803"}],"wp:attachment":[{"href":"https:\/\/biomedpharmajournal.org\/staging\/wp-json\/wp\/v2\/media?parent=29332"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/biomedpharmajournal.org\/staging\/wp-json\/wp\/v2\/categories?post=29332"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/biomedpharmajournal.org\/staging\/wp-json\/wp\/v2\/tags?post=29332"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}