Genes In Tooth Development

V.Vignesh; N. Aravindha Babu; N. Balachander; L. Malathi

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Genes In Tooth Development

Volume 8, (october Spl Edition)

V.Vignesh¹, N. Aravindha Babu², N. Balachander², L. Malathi²

¹Tagore dental college and hospital. ²Department of Oral Pathology and Microbiology(COCPAR), Sree Balaji Dental College and Hospital, Bharath University , Chennai.

DOI : http://dx.doi.org/10.13005/bpj/664

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ABSTRACT:

Teeth form as epithelial appendages such as hairs and glands. During development, reciprocal and sequential epithelial-mesenchymal interactions regulate processes such as proliferation, differentiation and morphogenesis. These interactions are mediated by conserved signaling pathways that are reiteratively used during development of all organs. Mutations in genes encoding molecules in the signaling pathways cause numerous abnormalities in craniofacial bones and teeth including missing or supernumerary teeth, and disturbances in formation of dentin and enamel. This article is regarding the genetic basis of tooth development, methods used to study it, and the genes that have been definitively implicated in the development of human dentition and the brief notice on the deformities caused due to the mutation of the these genes.

KEYWORDS:

Homeoboxgenes (Hox); MSX; DLX; PAX