Chrono Pharmaceutical Drug Delivery System
V. Ravichandiran1, V. Suba2, S. K. Umadevi2, G. Jayavasavi1, J. Kausalya1 and T. Saraswathy31Vels college of Pharmacy, Pallavaram, Chennai India.
2Department of Pharmacology, Vels college of Pharmacy,Pallavaram,Chennai.
3Madras Medical College, Chennai - 3 India.
Corresponding Author E-mail:sen03mpharm@gmail.com
Abstract: In the body under physiological conditions, many vital functions are regulated by transient release of bioactive substances at a specific time and site. Thus, to mimic the function of living systems and in view of emerging chronotherapeutic approaches, pulsatile delivery, which is meant to release a drug following programmed lag phase, has attracted increasing interest in recent years. In pursuit of pulsatile release, various design strategies have been proposed, broadly categorized into single-unit and multiple-unit systems. However, in recent pharmaceutical applications involving pulsatile delivery, multiparticulate dosage forms are gaining much favor over single-unit dosage forms because of their potential benefits like predictable gastric emptying, no risk of dose dumping, flexible release patterns and increased bioavailability with less inter- and intra-subject variability. Based on these premises, the aim of the present review is to survey the main multiparticulate pulsatile delivery systems, for which the swelling and rupturing; dissolution or erosion; and changed permeability of the coating membrane are primarily involved in the control of release. The development of low density floating multiparticulate pulsed-release dosage forms possessing gastric retention capabilities has also been addressed with increasing focus on the upcoming multiparticulate-pulsatile technologies being exploited on an industrial scale.
Keywords: PDDS-Pulsatile drug delivery systems; CR-controlled release; SR-sustained release Back to TOC