Formulation and Evaluation of Extended Release Matrix Tablet of Tramadol Hydrochloride using Hydrophilic Polymer
J. Kausalya*, S. Padmapriya, V. Vaijayanthi, S. K.Umadevi, Sreejith and B. Senthilnathan.Vels College of Pharmacy, Pallavaram, Chennai- 117 India.
Abstract: The objective of this study was to develop extended release matrix tablet of Tramadol hydrochloride using different combinations of hydrophilic polymers (HPMC, Carbopol, Xanthum Gum). The matrix tablets were prepared by direct compression technique. The pre and post compression characterization of blend and tablet were evaluated. The invitro dissolution studies revealed that the combination of HPMC and Carbopol in different concentration showed retard release of 65% at the end of 12th hour and more than 95% at the end of 24th hour, thereby showing good release pattern necessary for ER tablet and exhibited good kinetic release coupled of diffusion and erosion. Hence hydrophilic polymer HPMC and Carbopol was found to extended release of highly water soluble drug, Tramadol hydrochloride.
Keywords: Tramadol hydrochloride; hydrophilic polymer; extended release matrix tablet Back to TOC