In Vivo Antidiabetic Potential of Artocarpus Heterophyllus Plant Seeds in Streptozotocin-Induced-Diabetic Rats
Omair Hasan Osmani¹*, Dhanasekar Sathish Sekar¹, K.L. Senthil Kumar¹, Ram Kumar Sahu² and Amit Roy³¹Department of Pharmacognosy, Padmavathi College of Pharmacy, Dharmapuri India.
²Department of Pharmacognosy, Oriental College of Pharmacy, Bhopal India.
³Columbia College of Pharmacy, Mandhar, Raipur India.
Corresponding Author E-mail:b_omair2006@yahoo.co.in
Abstract: Artocarpus heterophyllus is a medicinal plant, used by herbalist for treating various diseases, one of which is Diabetes mellitus. The aim of this study was to investigate the antidiabetic potential of Artocarpus heterophyllus plant seed powder. This was tested in normal and strepozotocin induced diabetic rats using oral administration of ethanol extracts of Artocarpus heterophyllus. After the oral administration of ethanol extract at doses of 400 mg/kg body weight, blood glucose levels were monitored at specific intervals and found significantly lowered the blood glucose level. Glibenclamide was used as a standard drug at a dose of 0.25 mg/kg. The experimental data revealed that extract has significant antihyperglycaemic activity in streptozotocin-induced rats compared to standard drug. The extracts seem promising for the development of an oral antidiabetic medicine.
Keywords: Antidiabetic; Lipid profile; Artocarpus heterophyllus; Strepozotocin; Glibenclamide Back to TOC