The Combination of Belimbing Wuluh Fruit (Averrhoa Bilimbi L.) and Leaves of Tapak Dara (Catharanthus Roseus G.) From Indonesia as a Candidate Hypoglycemic Agents and Thin Layer Chromatography Profiles
EM Sutrisna1 and Tanti Azizah Sujono21Department of Pharmacology of Faculty of medicine and Faculty of pharmacy of Universitas Muhammadiyah Surakarta 2Department of Pharmacy of Faculty of Pharmacy of Universitas Muhammadiyah Surakarta Corresponding Author Email : Em.Sutrisna@ums.ac.id
Abstract: The aim of this study was to evaluate the combination of 70% ethanol extract of Averrhoa bilimbi L. (A bilimbi L.) fruit & Catharanthus roseus G. (C. roseus G) leaves extracts in lowering blood glucose levels. Twenty-five male Wistar rats were divided into 5 groups. All rats were weighed on day 0, then induced by alloxan 150 mg/KgBW (ip). Group I was treated with 0.126 mg/200 gBW glibenclamide (po); Group II was treated by CMC Na 2 ml/200 gBW po; Group III; IV; and V were treated by the extract combination of A. bilimbi L and C. roseus G 40:40; 40:80; and 80:40 mg/200 gBW respectively, for 15 consecutive days (po). The results showed that the combination A. bilimbi L and C. roseus G doses 40:80 and 80:40 mg/200 gBW had the effect of lowering blood glucose levels in 7 days, but couldn’t prevent renal damage by induction of alloxan.
Keywords: Belimbing wuluh (Averrhoa bilimbi L.); Tapak dara (Catharanthus roseus G.); candidate hypoglycemic Back to TOC