Formulation and Characteristics of Film Forming Hydrogel (FFH) of Yellow Root Extract (Arcangelisia Flava (L.) Merr.) As Wound Healing for Burns
Rahmi Annisa
, Yasmin Erly Agustin, Nabila Rahmadani and Roihatul MutiahDepartment of Pharmacy, Faculty of Medicine and Health Science, Universitas Islam Negeri Maulana Malik Ibrahim, Malang, Indonesia
Corresponding Author E-mail:roiha@farmasi.uin-malang.ac.id
Abstract: The aim of this study was to determine the effect of different concentrations of yellow root extract (Arcangelisia Flava (L.) Merr.) and film-forming hydrogel (FFH) polymer on the physicochemical characteristics and stability of the preparation. The method for making FFH is carried out using varying concentrations (%) of 0,5 extract, 1, and 1,5, as well as variations in concentration (%) of PVP and PVA (2,8:15,2; 2,8:17,2; 2,8:19,2). F1 – F9 were evaluated for physicochemical characteristics, including organoleptic, pH, spreadability, adhesive power, drying time, viscosity, stickiness, and mechanical properties. Next, freeze-thaw stability and data analysis were carried out using the LSD test at a confidence level of 95%. This research indicates that the FFH formulation of yellow root extract has good characteristics in the F1 formula with an extract concentration of 0.5% and a concentration (%) of PVP and PVP polymer (2.8:15.2), which meets all physicochemical characteristic tests. The results of data analysis using SPSS showed that the extract concentration and polymer concentration had a significant effect (0.05<0.05) on the characteristics and stability of the Yellow Root Extract Film Forming Hydrogel (FFH) preparation.
Keywords: Burns; Film Forming Hydrogel; Polymers; Wound; Yellow Root Extract Back to TOC