Formulation and Evaluation of Herbal Tablets from The Shimshin-6 Prescription and Its Effect on Postpartum Involution in Rats
Dejidmaa Buyantogtokh1
, Erdenechimeg Chuluunbaatar2*, Anu Altangerel1, Nyamdolgor Uranbileg3 and Chimedragchaa Chimedtseren11Department of Pharmacology, Research center, Institute of Traditional Medicine and Technology, Ulaanbaatar, Mongolia.
2Department of Chemistry and Technology, Research center, Institute of Traditional Medicine and Technology, Ulaanbaatar, Mongolia.
3Department of Pathology, Institute of Veterinary Medicine. Ulaanbaatar, Mongolia.
Corresponding Author e-mail: Erdenechimeg.ch805@gmail.com
Abstract: The Shimshin-6 prescription has been used to treat female patients for blood clots, back and waist pain, and menstrual cramps. It is intended to support the recovery of the uterus after both childbirth and abortion. The purpose of this study is to create a tablet form of the Shimshin-6 formula and examine its effects on the recovery of the uterus after childbirth. The granules were developed using wet granulation, and the tablets were made using a direct compression method. Our test product in tablet form was manufactured following the quality parameters specified in the Mongolian National Pharmacopoeia. Shimshin-3 tablet was considered the best formulation; it used 5% cane sugar as a binder. In this study, Shimshin-6 treatment significantly reduced the uterus index and blood estrogen levels compared to the control group showing no difference in progesterone concentration. We found that Shimshin-6 decreased Tumor Necrosis Factor (TNFα) and regulated growth factors in postpartum rats. Shimshin-6 also regulated postpartum uterine recovery, as indicated by histological analysis. Our results showed the infiltration of inflammatory cell and hemorrhagic changes in the uterine wall. In conclusion, the formulation and evaluation of herbal tablets were satisfactory, and it has been found to enhance uterine recovery postpartum in rats.
Keywords: Cane sugar; Herbal formulation; Involution of uterus; Rheum undulatum Postpartum care. Back to TOC