Targeting Autophagic Pathway in Oral Cancer Therapy Through Phytoconstituents: A Short Review
Soumya Satpathy 1
, Sanat Kumar Bhuyan 2 and Ruchi Bhuyan1*,1Department of Medical Research, IMS and SUM Hospital, Siksha O Anusandhan Deemed to be University,
2Institute of Dental Sciences, SOA Deemed to be University, Bhubaneswar, Odisha, India.
Corresponding Author E-mail: ruchibhuyan@soa.ac.in
Abstract: Oral cancer was recognized as the most common type of cancer in South Asian countries including India. As concurrent chemoradiotherapy leads to various associated new problems, there is always a need for improved therapies without side effects. Natural plant products used since ancient times may fill the gap. Phytoconstituents can activate various cell death pathways, such as apoptosis, autophagy, or pyroptosis to treat oral tumors. Numerous studies have already been done to date to enlighten the detailed mechanism of the use of phytoconstituents in these cell-signaling pathways. As the majority of the studies emphasized the apoptotic pathway, the least reports are found on autophagy. ‘AMPK’ and ‘mTOR’ have been acknowledged to be the key signaling compounds that modulate autophagy. Therefore the objective of this article is to discuss the mechanism of autophagy concerning phytoconstituents in the treatment of oral carcinoma.
Keywords: AMPK; Autophagy; mTOR; Oral cancer; Phytoconstituents Back to TOC