Helicobacter Pylori Infection and Microalbuminuria in Diabetic Patients
Ashraf Askar 1, Adel El-Sayed 1, Lyla Yosef 1, Osama Abdelaal 1,  Eman Sabet 2, Ahmed Sadek 3, Wafaa Wafy 4, Mina Wassef Girgiss 5, Moushira Zaki 6 and Eman R. Youness 7*

1Department of Internal Medicine, Faculty of Medicine, Sohag University.

2Clinical Pathology Department, Faculty of Medicine, Sohag University.

3Department of Hepatology and Gastroenterology, Theodor Bilharz Research Institute, Imbaba Giza, Egypt.

4Public Health Department, Theodor Bilharz Research Institute, Imbaba Giza, Egypt.

5Medical Department, Medical Researches and Clinical Studies Institute, National Research Centre Cairo, Egypt.

6Department of Biological Anthropology, Medical Researches and Clinical Studies Institute, National Research Centre Cairo, Egypt.

7Department of Medical Biochemistry, Medical Researches and Clinical Studies Institute, National Research Centre Cairo, Egypt.

Corresponding Author E-mail: hoctober2000@yahoo.com

Abstract: Microalbuminuria is defined as an elevated urine albumin to creatinine ratio of 30-300 g/mg. It has been recognized as a strong indicator of the onset of diabetic nephropathy. Damage to vascular endothelium and systemic inflammation can result from H. Pylori infection. Thus, it stands to reason that the resulting glomerular damage might raise the excretion of albumin in the urine. Our goal was to find out if H. pylori and microalbuminuria are related in individuals with diabetes mellitus (DM). This is a case – control observational study conducted in  6 months. Random blood glucose, Urinary Albumin Creatinine Ratio (UACR) and H. Pylori Antigen (H. Pylori antigen) in stool were measured. To minimize possible confounding factors, selecting various matching variables was put  consideration when choosing the control group. Therefore, most of the matching variables of the study were comparable in both groups makes the results of studying of H. pylori as a possible risk factor for microalbuminuria greatly accurate. we concluded that H. pylori infection is highly suggested to be an independent risk factor for the  development of microalbuminuria in diabetic patients. As proven by the present work; a highly significant statistical relationship between H. pylori infection and  the presence of microalbuminuria in patients with diabetes.

Keywords: Diabetic patients; Helicobacter Pylori seropositivity; low grade inflammation; UACR microalbuminuria

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