Evaluation of the Antifungal Activity of Fluconazole Nanovesicles Against Aspergillus fumigatus
Ahmed L. Osman1*
, Abd Elgadir A. Altoum1 , Devapriya Finney Shadroch1 Asaad MA. Babker1, Hesham Elashmouny2 , Nourhan Khaled Hassan2, Rania Moataz El-Dahmy3, Mohamed Haider4,5 and Ibrahim Elsayed2,61Department of Medical Laboratory Sciences, College of Health Sciences, Gulf Medical University. Ajman, United Arab Emirates
2Department of Pharmaceutical Sciences, College of Pharmacy, Gulf Medical University, Ajman, United Arab Emirates
3Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, October 6 University, Cairo, Egypt
4Department of Pharmaceutics and Pharmaceutical Technology, College of Pharmacy, University of Sharjah, 27272, Sharjah, United Arab Emirates
5Research Institute of Medical and Health Sciences, University of Sharjah, 27272, Sharjah, United Arab Emirates
6Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Cairo University, Cairo, Egypt.
Corresponding Author E-mail: dr.ahmed@gmu.ac.ae
Abstract: Fluconazole is potent triazole drug used as effectively anti-fungal for treating a variety of local and systemic fungal infections. This drug is sparingly soluble in water. The objective of this research was to statistically optimize nanovesicular formulations contain fluconazole to improve its antifungal effect. The nanovesicular formulations were composed of Tween® 80, cetyl alcohol, and chitosan. The prepared nanovesicular formulations were investigated for their zeta potential, polydispersity index, particle size, and encapsulation efficiency. The nanovesicular that has been optimized formulation was consist of tween/cetyl alcohol ratio of 15:1 and 0.1% chitosan. Additionally, the optimized formulation increased significantly in fluconazole release ratio and extent in comparison to the suspension form of the drug. The find that fluconazole nanovesicles had a better effect and lower MIC when compared to the aqueous fluconazole suspension. Finally, the optimized nanovesicles can be considered a promising nanocarrier for delivery of fluconazole to increase its systemic antifungal efficacy.
Keywords: Antifungal Activity; Fluconazole; Central Composite Design; In Vitro Release; Nanovesicles Back to TOC