Therapeutic Potential of Coriander (Coriandrum sativum) Seeds Extract Treatment on Hematological and Biochemical Parameters in Healthy and Trichinella spiralis Infected Mice
Areej Jameel M. Alghabban
Biology Department, Faculty of science, University of Tabuk, KSA.
Corresponding Author E-mail: a_alghabban@ut.edu.sa
Abstract: The smallest known human nematode parasite is Trichinella spiralis (T. spiralis). A parasitic zoonosis that can be found anywhere in the world is trichinellosis. When a host consumes raw meat contaminated with Trichinella larvae, the larvae mature into adults in the host's stomach in 5 to 6 days. The females subsequently give birth to additional larvae, some of which eventually make it to muscle cells after travelling through blood channels. These cells allow infective larvae to survive for years because, after two to three weeks, the larvae become infectious and the host cell transforms into a nurse cell. The current study used parasitological assessment to count adult worms and encysted larvae at 5 weeks after infection (5WPI) to determine the effect of coriander seeds extract (CSE) against encysted larvae further to hematological and biochemical tests. Current results revealed that; Trichinella spiralis experimentally infection (5WPI) induced significant elevation in white blood cells (WBCs) counts, neutrophil, monocyte, eosinophil percentage, alanine transaminase (ALT), aspartate transaminase (AST), alkaline phosphatase (ALP), urea, creatinine and a significant depletion hemoglobin (Hb), red blood cell (RBC) count, hematocrit (HCT), mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), platelet count (PLT), lymphocytes percentage, albumin, total proteins as compared to control and CSE groups. Meanwhile, treatments of 5WPI with CSE (5WPI+CSE) revealed a significant reduction in the number of Trichinella spiralis encysted larvae and improvements in all hematological parameters, liver and kidney functions as compared to 5WPI. We can conclude that; CSE could be an alternative method for treatment against trichinellosis.
Keywords: Coriander seeds; kidney functions; Liver; Mice; Trichinella spiralis Back to TOC