Insilico Assessment of Phytoconstituents in Myxopyrum Smilacifolium Blume Against Arthritis
Raveesha Peeriga1*
, S.A. Mohamed Shiek Arabath2, Krishnaveni Manubolu3, Bency Baby Thelappilly4 and Lakshmi Chakradhar Yarlagadda51V. V. Institute of Pharmaceutical Sciences, Gudlavalleru Post, Krishna District, Andhra Pradesh, India.
2Arulmigu Kalasalingam College of Pharmacy, Krishnan Kovi, Virudhunagar District, Tamil Nadu, India.
3Al shifa College of Pharmacy, Perinthalmanna, Kerala, India.
4Narayana Pharmacy College, Chinthareddypalem, Nellore, Andhra Pradesh, India.
5G.S.L. Medical College, Rajahmundry, Andhra Pradesh, India.
Corresponding Author E-mail: gsrivastava@rmlau.ac.in
Abstract: Myxopyrum smilacifolium Blume geographical occurrence is southern part of India and its usage for the treatment of various diseases has been marked in Traditional Medicine. The present study was aimed to examine the phytoconstituents in Myxopyrum smilacifolium Blume for antiarthritic activity by insilico approach. Antiarthritic activity of phytoconstituents in Myxopyrum smilacifolium Blume was performed by using software Autodock 4.0. For each phytoconstituents the pharmacokinetic parameters are also assessed by online tools. The study revealed that phytocompounds, Arenarioside, Verbascoside and Myxopyroside showed docking score of about -16.4 kcal/mol, -10.6kcal/mol and -6.5 kcal/mol comparatively high when compared with the docking score of standard Ibuprofen of about -6.2 kcal/mol. It had proven to posses the inhibition activity against inflammatory mediator as it shown a good binding affinity between ligand and the receptor site COX-2. The evaluated pharmacokinetic parameters of the only 3 phytoconstituents obeyed Lipinski’s rule of 5. Arenarioside, Verbascoside and Myxopyroside are the phytoconstituents of Myxopyrum smilacifolium Blume shown high docking score and it can be explored further for SAR and simulation studies are needed to ensure the antiarthritic activity.
Keywords: Arenarioside; Docking; In silico; Lipinskis; Myxopyrum Back to TOC