Protective Effect of Prosopis Farcta Fruit Aqueous Extract Against Oxidative Stress Caused By Ethanol in Albino Rats
Mustafa K. Mushatet1*
, Thikra abd jary2, Asaad Abbas khalaf 1 and Mustafa Abbas Alqabbany 31 Kerbala University, College of Nursing- Branch of basic sciences, Kerbala, Iraq
2 Al-Ameed University, College of Medicine- Branch of Biochemstry, Kerbala, Iraq
3 Kerbala University, College of Sciences- department of Biology, Kerbala, Iraq
Corresponding Author E-mail: mustafa.k@uokerbala.edu.iq
Abstract: Prosopis farcta was previously used in folk medicine as a dry fruit to relieve pain before its active biological components that contribute to this were known. This study assessed the effectiveness of a dry fruit extract of P. farcta by measuring the indicators of inflammation in albino rats after they were dosed with ethanol. As such, looking at the antioxidant potential of P. farcta fruit aqueous extract (PFFAE) in resistance to ethanol's harm in rats given ethanol showed a notable increase in serum C reactive protein (CRP), malondialdehyde (MDA), CRP/ALB ratio (CAR), and WBC count. At the same time, glutathione peroxidase (GPx) and albumin were markedly reduced. PFFAE diminished ethanol-induced amounts of CRP, MDA, and CAR in plasma; additionally, it strengthened the ethanol-induced decline in GPx activity, and albumin had no apparent effect on the ESR level. Consequently, the current findings demonstrate that PFFAE counteracts the toxicity of ethanol and has a protective impact against the ethanol effect.
Keywords: Albumin; CAR; Glutathione peroxidase; Inflammation; malondialdehyde; Prosopis farcta Back to TOC