Protective Effect of Aspirin Against Gentamicin-Induced Hepatotoxicity in Rats Model
Asmaa Moafa1,2
, Sara A. Aldossary1, Mohammed Al mohaini3 and Abdulkhaliq J. Alsalman.41Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, 31982 Alahsa, Saudi Arabia.
2Pharmacy Services Department, Johns Hopkins Aramco Healthcare (JHAH), Saudi Arabia.
3Basic Sciences Department, College of Applied Medical Sciences, King Saud bin Abdulaziz University for Health Sciences, King Abdullah International Medical Research Center, Alahsa 31982, Saudi Arabia
4 Department of Clinical Pharmacy, Faculty of Pharmacy, Northern Border University, Rafha 91911, Saudi Arabia.
Corresponding Author E-mail: saldossary@kfu.edu.sa
Abstract: Gentamicin is an extensively used antibiotic with potent antimicrobial exertion, but its clinical mileage is limited by its eventuality to induce hepatotoxicity. This study aimed to probe the defensive effect of aspirin against gentamicin-convinced hepatotoxicity in a rat model. Adult manly Wistar rats were divided into four groups control, aspirin, gentamicin, and aspirin- gentamicin. The creatures were treated for 15 successive days, and colorful biochemical parameters were estimated. Pre-treatment with aspirin significantly downgraded the adverse goods of gentamicin on liver weight. It also eased the elevation of serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) situations, indicating the preservation of liver function. Aspirin treatment suppressed hepatic lipid peroxidation, as substantiated by a reduction in malondialdehyde (MDA) situations. likewise, it averted the reduction of glutathione (GSH) situations and catalase exertion convinced by gentamicin administration. These findings suggest that aspirin exerts a hepatoprotective effect by reducing oxidative stress and enhancing antioxidant defense mechanisms. The protective mechanisms of aspirin may involve its anti-inflammatory properties, as well as its antioxidant effects. Aspirin has the potential to inhibit inflammation-induced liver injury and modulate signaling pathways involved in cell survival and apoptosis. However, further investigations are needed to elucidate the precise molecular mechanisms underlying its protective effects. Overall, pre-treatment with aspirin demonstrated a protective effect against gentamicin-induced hepatotoxicity in this rat model. It mitigated liver damage, preserved liver function, and enhanced antioxidant defense mechanisms. These findings suggest that aspirin could be a potential therapeutic agent for the prevention and management of drug-induced liver injury. Further studies, including clinical trials, are necessary to determine the optimal dosage, duration, and safety profile of aspirin in humans.
Keywords: Aspirin; Gentamicin; Hepatotoxicity; Rats Back to TOC