Protective effect of Ethanolic Extracts of Syzygium Campanulatum leaf in Wistar Albino Rats Against Triton and Atherogenic Diet-Induced Hyperlipidemia
Nadira Noushida1
, Roopa P Nayak1*, Manodeep Chakraborty2, Thriveni Raunak Salian3 and Mohammed Gulzar Ahmed31Pharmacology Department, Yenepoya Medical College, Mangalore, Karnataka, India.
2Pharmacology Department, Himalayan Pharmacy Institute, Sikkim, India
3Pharmaceutics Department, Yenepoya Pharmacy College and Research Centre, Mangalore, Karnataka, India.
Corresponding Author E-mail: roopapnayak@yenepoya.edu.in
Abstract: Hyperlipidemia is characterized by an abnormal elevation in the major circulatory lipids and lipoproteins; this adversely affects the pathways of cholesterol transport. Syzygium campanulatum Korth is an evergreen shrub in the kingdom of Myrtaceae. Leaves are popular for their hepatoprotective, antiangiogenesis, and anticancer properties. The purpose of this research was to assess the antihyperlipidemic effect of ethanolic leaf extract of S. campanulatum in experimental rats against atherogenic diet-induced hyperlipidemia. During the 20 days, rats were fed an atherogenic diet mixed with standard pellets. The treatment of S. campanulatum (250/500 mg/kg) was given for 14 days. After 48 h blood samples from rats were collected, serum was collected for evaluation of lipoproteins (high-density lipoprotein, low-density lipoprotein, total cholesterol, triglycerides), and liver tissue was separated for evaluation of tissue antioxidants (superoxide dismutase, catalase, thiobarbituric acid reactive species, and glutathione). The results showed that when compared to rats on a normal diet, an atherogenic diet generated a substantial (p <0.001) decrease in serum HDL-C and a substantial (p <0.001) rise in blood TC, TG, and LDL-C. The hyperlipidaemic groups that received S.Campanulatum 250/500 mg/kg and Atorvastatin 10 mg/kg showed a substantial (p < 0.001) decrease in serum levels of TC, TG, LDL-C, and significant (p < 0.001) increase in HDL-C respectively, compared to rats with hyperlipidemia control. The study indicates that the ethanolic extract of S.Campanulatum has substantial antihyperlipidemic action, indicating that it might be a potential natural medicine used in addition to currently prescribed hyperlipidemia treatments.
Keywords: Atherogenic diet; Atorvastatin; Hyperlipidemia; Syzygium Campanulatum Back to TOC