Antioxidant, Antibacterial and Cytotoxic Activities of Artemisia judaica, Ruta graveolens and Suaeda monoica from Saudi Arabia

Saida S. Ncibi^1*, Aymen, M. Madkhali^2,3, Magbool E. Oraiby⁴, Jamilah A. Almalki¹, Hussein A. Khadashi⁶, Abdullah A. Mobarki⁵, Syam Mohan⁶and Hassan A. Hamali²

¹Department of Biology, College of Science, Jazan University, KSA.

²Department of Medical Laboratory Technology, Faculty of Applied Medical Science, Jazan University, Jazan, KSA.

³Medical Research Center, Jazan University, Jazan, Kingdom of Saudi Arabia.

⁴Poison control center Jazan, KSA.

⁵Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, Jazan University, Jazan, Kingdom of Saudi Arabia

⁶Substance Abuse and Toxicology Research center, Jazan University Jazan, KSA.

Corresponding Author E-mail:sncibi@jazanu.edu.sa

Abstract: Artemisia judaica, Ruta graveolens, and Suaeda monoica, indigenous plants to Jazan, second smallest region of Saudi Arabia, have several uses in the local folk medicine. This research aims to study the chemical composition of their methanol extracts and to explore some related biological activities. The different extracts Gas Chromatography Mass Spectroscopy profiling revealed the occurrence of many compounds within these extracts. Besides, this study revealed varied and selective antibacterial activities of these extracts. Ruta graveolens methanol extract was effective in inhibiting the growth of all tested microorganisms. Furthermore, they exhibit an interesting cytotoxic effect on human breast cancer cell lines, especially Artemisia judaica methanol extract. These findings suggested that Artemisia judaica (Asteraceae), Ruta graveolens (Rutaceae), and Suaeda monoica (Chenopodiaceae) could be natural sources for the discovery of new drugs.

Keywords: Antibacterial; Antioxidant; Artemisia Judaica; Cytotoxic; Suaeda Monoica; Ruta Graveolens

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