Anti-Diabetic Effects of Pomegranate Peel Extract and L- Carnitine on Streptozotocin Induced Diabetes in Rats
Anwar M. M. Ezz*
, Omar N. ALheeti2, Ahmed F.Hasan3, Somaia Zaki and Ghada A. Tabl
1Department of Zoology , Faculty of Science; Tanta University, Egypt.
2Department of Applied Chemistry ,College of Applied Science, University of Fallujah ,Iraq.
3Biotechnology Research Center, Al-Nahrain University, Baghdad, Iraq.
Corresponding Author E-mail: anwarezz237@gmail.com
Abstract: Type 2 diabetes mellitus is a far reaching ongoing metabolic problem portrayed by hyperglycemia and related with a few intricacies like hyperlipidemia. The current study aimed to study the anti-diabetic efficacy of pomegranate peel extract and L-carnitine on streptozotocin-induced diabetes mellitus in rats. A total of 70 male rats were divided into 7 groups (normal rats treated with the pomegranate peel extract and L-carnitine; rats given a high-fat diet to cause hyperlipidemia, this rats given low-dose intraperitoneal streptozotocin injections to cause type II diabetes; diabetic rats given PPE and L-carnitine orally every day for 12 weeks. Measurements of body mass, blood sugar, lipid profile and antioxidant enzyme activity were made.Results: The treatment group that received PPE + L-carnitine showed a significant decrease in weight, blood glucose, cholesterol, triglycerides and low-density lipoprotein were significantly reduced, while high-density lipoprotein levels were significantly increased. Superoxide dismutase levels were increased, catalase and Nuclear Factor Erythroid-derived 2 (Nfe2) in diabetic rats treated with PPE and L-carnitine, while Malondialdehyde levels decreased significantly. According to the results of the study, PPE and L-carnitine had significant anti-hyperglycemic, hypolipidemic, and antioxidant benefits after 12 weeks of treatment in streptozotocin-induced diabetic rats.
Keywords: Diabetic Mellitus; Pomegranate Peel Extract; L-Carnitine Back to TOC