The Relationship of CCND1 RS614367 Polymorphism with Clinicopathological Features in Breast Cancer Subjects
Putu Anda Tusta Adiputra1*
, I Gede Putu Supadmanaba2, I Gede Krisna Arim Sadeva3, Anak Agung Bagus Putra Indrakusuma3, Putri Ayu Wulandari3, Desak Made Wihandani21Division of Surgical Oncology, Department of Surgery, Faculty of Medicine, Udayana University, Prof IGNG Ngoerah General Hospital, Denpasar, Bali, Indonesia
2Department of Biochemistry, Faculty of Medicine, Udayana University, Denpasar, Bali, Indonesia
3Faculty of Medicine, Udayana University, Denpasar, Bali, Indonesia
Corresponding Author E-mail:andatusta@unud.ac.id
Abstract: Recent studies have shown that the CCND1 rs614367 polymorphism increases the risk of breast cancer and its invasive nature. However, studies evaluating the relationship of the CCND1 rs614367 polymorphism based on the clinicopathology of breast cancer patients in Indonesia were still limited. This study is aimed to determine the CCND1 rs614367 polymorphism in breast cancer and its relationship with the patient's clinicopathology. Methods: This study was a cross-sectional study on 45 samples of breast cancer patients. After collecting demographic and clinical data, PCR and sequencing will be performed on all blood samples to determine the CCND1 rs614367 polymorphism. All variables that have been collected will be analyzed using SPSS version 25.0 to determine the relationship between the CCND1 rs614367 polymorphism and the clinicopathology of breast cancer patients. The CCND1 rs614367 gene polymorphism in breast cancer subjects showed that 25 (55.5%) and 20 (44.5%) subjects had C and T alleles. Subjects aged ≥ 50 years old had a significant 4.45 risk of having the T allele type (p=0.037). In addition, subjects with metastases (M1) were also at a significant 4.89 times risk of having the T allele type (p=0.015). Subjects with histological grade III also had a significantly 4.77 times risk of having the T allele type (p=0.013). In conclusion, there was a significant relationship between CCND1 rs614367 polymorphism and breast cancer subjects' clinopathology features (age, metastasis, and grade). More than half of the subjects with this polymorphism had the C allele.
Keywords: Breast Cancer; CCND1 rs614367; Clinicopathological; Polymorphism Back to TOC