Nanoparticles -A Booming Drug Delivery System in Chemotherapy

Shalu Verma^1*, Alka Singh², Gauree Kukreti², Meenakshi Bharkatiya³, Kiran Dobhal⁴, Tarun Parashar¹, Jyotsana Suyal¹, Vikash Jakhmola¹

¹Uttaranchal Institute of Pharmaceutical Sciences, Uttaranchal University, Dehradun, Uttarakhand, India

²School of Pharmaceutical Sciences and Technology, Sardar Bhagwan Singh University, Balawala, Dehradun, Uttarakhand, India

³B.N Institute of Pharmaceutical Sciences, B.N University, Udaipur, Rajasthan, India

⁴College of Pharmacy, Shivalik Campus, Dehradun, Uttarakhand, India

Corresponding Author E-mail:vermashalu339@gmail.com

Abstract: The current study proposed the “Nanoparticles -A Booming Drug Delivery System in Chemotherapy” is a Novel targeted approach which enhances the efficacy of chemotherapeutic agents by reducing the dose-related side effect as well as mortality rate a in patients due to its non-immunogenic, nontoxic nature. Drug bioavailability, drug solubility, drug biodistribution, drug resistance brought on by treatment, and nonspecific toxicity can all be improved with the development of nanoparticle chemotherapeutic drug delivery applications based on nanotechnology. It possesses active as well as passive targeting of tumour cells. Due to this reason, a wide range of chemotherapeutic agents like cisplatin, taxol, doxorubicin, and carboplatin are extensively utilized for treating cancer. Deep tissue penetration of nanoparticles is found to increase the enhanced permeability and retention (EPR) effect. There are some limitations with conventional drug delivery system which is minimized by utilizing nanoparticles as a drug delivery system. The current review has focused on targeted strategies and novel approaches in cancer treatment with nanoparticles.

Keywords: Bioavailability; Chemotherapy; Nanoparticles; Solubility; Targeted Therapy; Tumour

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