The Discovery of Drug Delivery from Development Film Forming Hydrogel for Wound Dressing Applications: A Systematic Review

Rahmi Annisa^1*, Retno Susilowati², Evika Sandi Savitri², Maharani Retna Duhita²  and Sharida Fakurazi³

¹Department of Pharmacy, Faculty of Medicine and Health Science, Universitas Islam Negeri Maulana Malik Ibrahim, Malang, Indonesia.

²Department of Biology, Faculty of Science and Technology, Universitas Islam Negeri Maulana Malik Ibrahim, Malang, Indonesia.

³Department of Human Anatomy, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang 43400, Selangor Darul Ehsan, Malaysia.

Corresponfing Author E-mail: rahmiannisa@farmasi.uin-malang.ac.id

Abstract: Film Forming Hydrogel is a dosage form that changes shape to film by solvent evaporation after being applied to the wound area. This study aims to present a study to develop film-forming hydrogels with a brief description of the membrane properties formulated from biopolymers for wound application. Over the last ten years, much effort has been conducted to develop new artificial polymeric membranes that meet the demanding requirements for topical applications such as skin wound care. Therefore, this study represents the ideal polymer specifications for wound dressing membranes, such as cross-linked hydrogels compatible with wound dressings. The results of the analysis showed that single-component hydrogels have low mechanical strength. Therefore, recent trends offer composite or hybrid hydrogel membranes to achieve a typical wound with various requirements to meet the characteristic aspects of film-forming hydrogels.

Keywords: Biomedical Applications; Film-Forming; Hydrogels; Membranes; Wound Dressings

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