Renoprotective Effects of Anthocyanins Against Uric Acid-Instigated Injury: Mini Review with a Special Emphasis on Purple Sweet Potato (Ipomoea batatas L.) Anthocyanins
Agung Nova Mahendra1,2*
, I Made Jawi1, Nyoman Mantik Astawa3, Putu Astawa4 and I Wayan Putu Sutirta-Yasa5 1Department of Pharmacology and Therapy, Faculty of Medicine, Universitas Udayana, Denpasar, Bali, Indonesia.
2Doctoral Study Program in Biomedical Science, Faculty of Medicine, Universitas Udayana, Denpasar, Bali, Indonesia.
3Virology Laboratory, Faculty of Veterinary Medicine, Universitas Udayana, Denpasar, Bali, Indonesia.
4Department of Orthopedics and Traumatology, Faculty of Medicine, Universitas Udayana and RSUP Prof I G. N. G. Ngoerah, Denpasar, Bali, Indonesia.
5Department of Clinical Pathology, Faculty of Medicine, Universitas Udayana and RSUP Prof I G. N. G. Ngoerah, Denpasar, Bali, Indonesia.
Corresponding Author E-mail:novamahendra@unud.ac.id
Abstract: Anthocyanins are ubiquitous phytoconstituents found in a wide array of natural products. Purple sweet potato (Ipomoea batatas L.) is an important source of anthocyanins, a group of flavonoids with various medicinal benefits. One of the medicinal benefits of anthocyanins is their protection against the detrimental effects of stressors such as uric acid. On the other hand, hyperuricemia and its associated effects are considered significant challenges in human health. Since kidneys are essential organs in uric acid handling and uric acid is associated with kidney disease, this review focuses on re-appraising the role of purple sweet potato anthocyanins as renoprotectors against uric acid-related pathobiology. Future studies regarding the potential of these anthocyanins as renoprotectors are also discussed.
Keywords: Anthocyanins; Ipomoea batatas L.; kidney; NLRP3 inflammasome; Nox4; Nrf2; Uric acid; Xanthine oxidase Back to TOC