Antiviral and Antidermatophytic Activity of a Compound Extracted from Cuminum Cyminum Seeds
M. M. Mohamadein1, R. M. Farrag2. and. A. A. I. Mekawey21The Regional Center for Mycology and Biotechnology, Al-Azhar University, Cairo-Egypt 2Collage of Applied Medical Science, Prince Sattam Bin AbdulAziz University, Al-Kharj, KSA.
Abstract: In vitro activity of EHP [1-(2-Ethyl, 6-Heptyl) Phenol], a natural compound purified from cumin seeds extract, was investigated against ten dermatophytic isolates; Trichophyton (n=5), Microsporum (n=4), and Epidermophyton (n=1), as well as three viruses; HAV, Cox B4, and HSV-1. The highest antidermatophtic activity was against T. fulvum and E. floccosum while T. terrestre exhibited the most resistant isolate followed by T. schoenleinii. MIC of EHP ranged from 2.5 to 25 µg/ml, however owing to cytotoxicity results, EHP concentrations up to 10 µg/ml are preferably used. EHP possessed antiviral activity against the investigated viruses with HAV being the most affected followed by Cox B4 and then HSV1 with a plaque reduction percentage of 70, 65, and 60, respectively.
Keywords: Cuminum cyminum; Viruses; Dermatophytes; EHP Back to TOC