Prevalence and Antimicrobial Susceptibilities of Bacteria Isolated from Circumcised and Non-Circumcised Women with Urinary Tract Infections in Different Gynecological Clinics in Khartoum Locality, Sudan
Manal Abdalla Ali Elatta1
, Wafaa Mohammed Abdalla1, Hind Haidar Ahmed1*, Tagwa Salah Ahmed2,3 and Samar M. Saeed11Department of Microbiology, College of Medical Laboratory Science, Sudan University of Science and Technology, Sudan, Khartoum – Sudan
2Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Jouf University, Saudi Arabia.
3Department of Parasitology, Medical Entomology, College of Medical Laboratory Science, Sudan University of Science and Technology, Sudan, Khartoum – Sudan.
Corresponding Author E-mail: Hindhaidar011@gmail.com
Abstract: Background: Urinary tract infections (UTIs) are one of the diseases that are widely spreading among women. A number of factors contribute to UTIs, including circumcision, which narrows the opening of the urinary system. Materials and Methods: This cross-sectional study was conducted from April 2019 to February 2021 to detect the frequency of antimicrobial-resistant bacteria isolated from circumcised women attending two Clinics, for Gyncology in Khartoum locality. Conventional methods were used for isolation, identification, and antimicrobial susceptibility testing. A total of 80 midstream urine samples (n = 80) were collected from all female eligible volunteers, of which 40 had been circumcised and 40 had not. Results: The study investigated 80 females aged 7-70 years, with a mean of 29.3 + 13.1 SD. There were 16/40 (40%) circumcised women who were married and 23/40 (60%) single, whereas for non-circumcised women there were 7/40 (17.5%) married and 33/40 (82.5%) single. Among the circumcised patients, 34/40 (85%) had growths compared to 6/40 (15%) of the non-circumcised participants, and UTIs were significantly associated with circumcision (P≤0.001). Circumcised females had a 32 times higher odd ratio (O.R) of UTIs than non-circumcised females. Escherichia coli was the most predominant isolate among circumcised and non-circumcised women (15(37.5%)). The isolated bacteria in circumcised women were moderately sensitive to Augmentin 22/34 (67.7%) and Gentamycin 20/34 (58.8%) compared to other antimicrobial agents; Ciprofloxacin 16/34(47.1%), Cefuroxime 12/34(35.3) and Amoxycillin 10/34 (29.4%) while all Gram negative rods were highly resistant to Nalidixic acid (100.0%). In contrast to non-circumised women; all isolated bacteria were highly sensitive to Gentamicin 6/6 (100.0%) and Cefuroxime 5/6(83.3%), and moderate sensitive to Augmentin 4/6 (66.7%) and Ciprofloxacin 4/6(66.7%). Also all isolated were highly resistant to Nalidixic acid (100.0%) and Amoxycillin 1/6 (16.7%). Conclusion: UTIs and antimicrobial-resistant bacteria were more prevalent among circumcised women than non-circumcised women. E.coli was the most prevalent bacteria among circumcised and non- circumcised women.
Keywords: Antimicrobial; Circumcised Women; Resistant Bacteria; Sudan; UTIs Back to TOC