Molecular Cytogenetic Characterization of Burkitt's Lymphoma Among Sudanese Patients
Abdulrab Ahmed M. Alkhanjaf 1
,Wala Eldin Osman Elradi2, Abdel Rahim Mahmoud Muddathir3 , Ream Elzain Abdelgadir4, Elharam Ibrahim Abdallah2 and Elhashimi E Hassan5*1Molecular Diagnostics, Clinical Laboratory Sciences Department, College of Applied Medical Sciences, Najran University, Najran, Saudi Arabia.
2Department of Hematology and Blood Transfusion, Faculty of Medical Laboratory Sciences, Alzaeim Alazhari University, Khartoum, Sudan.
3Department of Clinical Laboratory Sciences, Faculty of Applied Medical Sciences, Taibah University, Medina, Kingdom of Saudi Arabia.
4Hematology Department, Faculty of Medicine and Health Science- Kordofan University, Elobied- Sudan.
5Clinical Laboratory Sciences Department, College of Applied Medical Sciences, Najran University, Najran, Saudi Arabia
Corresponding Author E-mail: alhashimihassan2018@gmail.com
Abstract: Burkitt lymphoma, one of the two main types of B-cell non-Hodgkin lymphomas (B-NHL), is a cancer type that develops in the lymphatic system and is a very aggressive lymphoma. This study looked into the cytogenetic and molecular characteristics of Burkitt lymphoma in Sudanese individuals. Paraffin embedded tissue blocks associated to 34 people who had previously been diagnosed with burkitt's lymphoma and retained were studied as part of a retrospective cross-sectional study in Khartoum state, Sudan, in September 2017. The Soba Teaching Governmental Hospital and private histology laboratories provided these blocks. The analysis component included three translocations, including t(8;14) (q24;q32), t(8;22) (q24;q11), and t(2;8) (p12;q24) for 34 patients. We discovered that the majority of patients have t(8;14) (q24;q32), which was positive in 44.1% (15/34), while t(8;22) (q24;q11) verified in 17.6% (6/34) of patients. Only one (2.9%) displays a positive result for t(2; 8) (p12;q24). Although immune-phenotyping and morphological characteristics for BL were found in the study's 12 cases (35.3%), it is possible that these cases represent a different variety of Burkitt's lymphoma caused by different forms of translocation. According to the study's findings, t(8;14) (q24;q32) remains the most common chromosomal rearrangement among Sudanese individuals with BL. Nevertheless, translocation of BL variations may exist, necessitating the use of advanced tools like sequencing, as these variants may play a significant role in the development and prognosis of disease.
Keywords: BL: Burkitt’s lymphoma; Translocation Back to TOC