Effect of Antidiabetic Drugs on Blood Coagulation in Diabetic Patients
Mansha Dua1
, Suguna Sajja2*, Seeresha3 and Supriya Priyambada1Dr. Pinnamaneni Siddhartha institute of medical sciences and research foundation, Chinnavutapalli, Andhra Pradesh, India.
2Department of Pharmacology, Gandhi medical college, secunderabad, Telangana, India.
3Department of general medicine, Dr. Pinnamaneni Siddhartha institute of medical sciences and research foundation, Chinnavutapalli, Andhrapradesh, India.
4Department of pharmacology, Dr. Pinnamaneni Siddhartha institute of medical sciences and research foundation, Chinnavutapalli, Andhra Pradesh, India
Corresponding Author E-mail: suguna.pharmac@gmail.com
Abstract: Background-Diabetes mellitus (DM) is a common endocrine disorder. Prothrombin time (PT) and activated partial thromboplastin time (aPTT) are basic haematological indices to screen the coagulation status. Due to persistent hyperglycemia, glycation of proteins involved in clotting mechanism takes place which reduces their availability, thus affecting the clotting capacity. Method- An analytical observational study was conducted on 180 subjects by measuring their PT and aPTT, to observe the effect of antidiabetic drugs on blood coagulation and to compare these indices between treated and untreated diabetics. Results- A significant elevation of PT and aPTT in untreated diabetics when compared to controls was seen (PT (p<0.001); aPTT (p<0.05)). The effect of antidiabetic drugs showed normal mean values of PT and aPTT in treated group (p>0.05). Conclusion- the study revealed that significant elevation of PT and aPTT in untreated DM than non diabetic controls may be interpreted as tendency to bleed while effect of anti diabetic drugs shows normal mean values of PT and aPTT in treated group. This suggests that antidiabetic drugs either in combination or monotherapy may normalize PT and aPTT by reducing glycation of hemoglobin. Therefore, routine examinations of PT and aPTT are important to assess coagulation impairment in diabetes mellitus so as to prevent cardiovascular disease.
Keywords: Antidiabetic Drugs; blood coagulation; Diabetes; HbA1c; PT; aPTT Back to TOC