Molecular and Biochemical Characterization of Hypothyroid Patients in Chennai

Nibedita Dey¹, Smita Ayer², Rajeswary Hari³ and Kamatchi C^4*

¹Saveetha School of Engineering, SIMATS, Thandalam, Tamil Nadu, India

²Visionary RCM - CorroHealth, Hyderabad, Telangana, India.

³Department of Biotechnology,Dr.M.G.R Educational and Research Institute, Chennai, Tamil Nadu, India

⁴Department of Biotechnology,The Oxford College of Science, Bengaluru, Karnataka India.

Corresponding Author E-mail: ckamatchi@gmail.com

Abstract: The lifestyle disorders are taking a toll on many individuals. With the fast-paced life, it is difficult to control the diet and physical activity necessary for optimal living. Stress too has added up to the various aliments associated with the body. Thyroid diseases are found to be a major hormonal discomfort found in many Asians. Hypothyroidism is a special condition in which there is a deficiency in the thyroid hormone production. The present study was devised to provide a comprehensive data on the effect of fresh onset of hypothyroidism on patients in Chennai. The diagnosed patients were experimented for their biochemical and molecular profiles. There was a significant increase in the lipid and peroxidase profiles. The antioxidant enzyme content also saw a steep decrease in individuals with hypothyroidism. The presence of thyroid peroxidase gene was found to be present in most of the hypothyroid patients. The genes were found to be 320 and 422 bp in size for the amplified product. Therefore, we were able to suggest that there is a very inevitable relation between hypothyroidism and heart ailments. Prolonged and unmonitored hypothyroidism can lead to various other pathological conditions to manifest in the patient in the long run.

Keywords: Biochemical Profiling; Chennai; Exon 9; Fresh Cases; hypothyroidism

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