Antihyperuricemia Activity of Vanilla (Vanilla planifolia Andrews) Fruits Ethanol Extract to Male Mice (Mus musculus L.)
Endang Nurcahyani1*
, Novita Herliani2 and M Kanedi21Applied Biology Study Program, Faculty of Mathematics and Natural Sciences, University of Lampung, Bandar Lampung 35145, Lampung, Indonesia
2Biology Study Program, Faculty of Mathematics and Natural Sciences, University of Lampung, Bandar Lampung 35145, Lampung, Indonesia.
Corresponding author E-mail: endang.nurcahyani@fmipa.unila.ac.id
Abstract: Hyperuricemia is a disease caused by an increase in uric acid levels in the blood over the normal level. Increased uric acid levels happen because the levels of purines in the body are quite high, so that the breakdown of purines into uric acid increases. This study used dried vanilla fruit extract using 60% ethanol solvent. The test animals used were 24 mice which were divided into 6 groups namely group Kn (standard feed), group K- (induced with suspension of chicken liver), group K + (induced by suspension of chicken liver and given allopurinol 10 mg / kgBB), group treatments P1, P2, and P3 were induced by suspension of chicken liver and vanilla fruit extract with doses of 50 mg / kgBB, 100 mg / kgBB, and 200 mg / kgBB respectively. Statistical data analysis using ANOVA (Analysis of Variance) through the SPSS 15.0 program with a level of α = 5% and continued with Duncan test at the level of α = 5%. The results of this study showed that vanilla fruit extract treatment P1, P2, and P3 had potential activity of antihyperuricemia, because it can reduce blood uric acid levels in mice induced by the chicken liver. The antihyperuricemia activity of vanilla fruit extract is comparable to the standard allopurinol chemical drug in reducing blood uric acid levels in mice statistically.
Keywords: Allopurinol; Antihyperuricemia; Uric Acid; Vanilla planifolia Andrews; Xanthine oxidase Back to TOC