Performance of Two Rapid Antigen Detection Tests for Detecting COVID-19 Compared to RT-PCR in Indonesia
Anak Agung Gede Budhitresna1,2*, Dewa Putu Surawan1,3, Ratna Kartikadewi1, Adi Harta Yoga1, Putri Permana Lestari1, Nyoman Trisna Sumadewi1
and Sri Masyeni1,31Department of Internal Medicine, Faculty of Medicine and Health Sciences, Universitas Warmadewa, Denpasar, Bali, 80235, Indonesia
2Department of Internal Medicine, Sanjiwani Hospital, Gianyar, Bali, 80235, Indonesia
3Department of Internal Medicine, Tabanan General Hospital, Tabanan, Bali, 82121, Indonesia
Corresponding Author E-mail:agbudhitresna@yahoo.com
Abstract: Antigen tests to screen coronavirus disease 2019 (COVID-19) is effective in symptomatic patients, leading to its wide usage in informing whether the person is COVID-19 positive or negative. Our current work had an objective to investigate the diagnostic performance of two antigen-detecting rapid diagnostic tests (Ag-RDTs) which are commonly used in Indonesia. A cross-sectional study was carried out to compare specificity, sensitivity, as well as expected predictive values of Anhui Ag-RDT and Lungene Ag-RDT by comparing the results with that obtained from real-time reverse transcription-polymerase chain reaction (RT-PCR) assay. A total of 98samples were tested for both Ag-RDTs and RT-PCR. The median value of the patients age obtained to be 41.78 years old (interquartile range: 1 to 91 years old). The proportion between female and males was: 52.53% vs 47.47%. The sensitivities of Anhui Ag-RDT and Lungene Ag-RDT were 55.56% and 51.58%, where both Ag-RDTs had specificity of 100%. In conclusion, sensitivity values of Lungene Ag-RDT and Anhui Ag-RDT are similar, where both possess 100% specificity with zero false-positive results. Both of the investigated Ag-RDTs are useful since positive results are likely to be COVID-19 positive.
Keywords: COVID-19; Ct value; Diagnostic Performance; Rapid Antigen Test; RT-PCR Back to TOC