Effect of Holoptelea Intigrifolia Bark Extract on Radical Scavening and 5’-Lipoxygease Activities.

M. Rama Rao^1*, S. V. Raja Gopal², I. Bhaskar Reddy, A. D. Naveen Kumar, A. Ramesh and T. Kartika

¹Department of Biochemistry,College of Science, GITAM Univeristy, Visakhapatnam.

²Department of Biotechnology, College of Science, GITAM Univeristy, Visakhapatnam  (India).

Corresponding Author E-mail:: ramaraomalla@rediffmail.com

Abstract: Holoptelea intigrifolia is traditionally used for the treatment of inflammatory disease, hemorrhoids. The role of free radicals has been proved in several diseases of inflammatory origin. To understand the pharmacological actions in inflammatory diseases, different types of radical scavenging and 51-lipoxygenase inhibitory activities of methanol extract of bark of H. intigrifolia have been investigated. Methanol extract exhibited significant radical scavenging activities with IC50 values of 105, 115, 265 and 105 mg/ml against 2, 2-diphenyl-1-picrylhydrazyl, super oxide, hydroxyl and nitric oxide radicals respectively. It also showed considerable inhibitory activity against 51-lipoxygenase with IC50 of 55.05 mg/ml. These results can contribute to understand the mechanism involved in the anti-inflammatory effects of the bark extract.

Keywords: Inflammatory disease; hemorrhoids; nitric oxide radical; super oxide radical

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