Oxidative Stress: Assessment of Thiobarbituric Acid Reactive Substances Value in Overweight Asthmatic Children
Sameh Abdelaziz Mansour1, Mohammed Abdel Malik Hassan Essa1, Hoda Hegazy Ahmed2, Mohammed Elsayed Abo-ghabsha3, Mahmoud Mohammed Mohammed Metwally3, Aliaa Ahmed Wahby4, Mohamed Mahmoud Abd Elmohsen1, Nagwa Abdallah M. Ismail2 and Mohamed Ahmed Abdel Mawla21Pediatric Department, Al-Azhar University, Cairo, Egypt.
2Pediatric Department, National Research Center, Cairo, Egypt.
3Clinical Pathology, Department Al-Azhar University, Cairo, Egypt.
4Clinical Pathology, Department National Research Center, Cairo, Egypt.
Corresponding Author E-mail: drmohamedahmed85@yahoo.com
Abstract: Nowadays bronchial asthma and increased body weight represent major problems in children. Asthmatic attacks in obese patients are not well controlled using the conventional treatment regimens. Asthma has been associated with increased systemic and exhaled levels of hydrogen peroxide and thiobarbituric acid-reactive products in expired breath condensate of asthmatic patients. Thiobarbituric acid reactive substances formed from peroxidation of lipids. The aim of the Study is to show the action of Thiobarbituric acid reactive substances activity in asthma among overweight children suffering from asthma and to detect the connection between this biomarker and the etiology, degree of severity among children with bronchial hypereactivity. The study is cross-sectional study, was conducted on Egyptian children on regular follow up at the outpatients pediatric allergy clinic in Bab El-shariea university Hospital, Al-Azhar University. The study group included 96 child divided into 4 groups. Group A which included overweight children with (mild persistent asthma). Group B which included non-overweight children with (mild persistent asthma).Group C which included overweight non-asthmatics children and Group D The control group (non-overweight non-asthmatics). The results showed significant increase in the Thiobarbituric acid reactive substances level in Overweight asthmatic patients in relation to non-overweight patients with asthma. We found that they can distinguish asthma controlled patients from non-asthma controlled patients. This study showed high level of oxidative stress with high asthma severity as measured by Thiobarbituric acid reactive substances. These substances were good markers of relation between bronchial hyper activity and oxidative stress which became high with asthma severity.
Keywords: Asthma; Obesity; Severity Back to TOC