High Performance Liquid Chromatography: Recent Patents and Advancement
Chanchal Bhati1, Neha Minocha2, Deepika Purohit3, Sunil Kumar3, Manish Makhija3, Sapna Saini4, Deepak Kaushik5 and Parijat Pandey1*

1Department of Pharmaceutical Sciences, Gurugram University, Gurugram – 122018, Haryana, India.

2School of Medical and Allied Sciences, K. R. Mangalam University, Gurugram – 122013, Haryana, India.

3Department of Pharmaceutical Sciences, Indira Gandhi University, Meerpur, Rewari – 123401, Haryana, India.

4PDM School of Pharmacy, Karsindhu, Safidon, Jind - 126112, Haryana, India.

5Department of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak – 124001, Haryana, India

Corresponding Author E-mail: parijatpandey98@gmail.com

Abstract: Background: Chromatography is defined as a set of techniques that are used for the separation of constituents in a mixture. Introduction: High-Pressure Liquid Chromatography or High-Performance Liquid Chromatography (HPLC) is known as a specialized technique in which columns as well as liquid chromatography are used in the separation, characterizationand investigation of the active moieties existing in the mixture. Objective: Current review focuses on the HPLC technique, including its principles, instrumentation, types, applications, advancements, and patents. Result: HPLC technique is important both for quantitative as well as qualitative analysis and is used for the evaluation of biological and pharmaceutical samples. It is the safest, most versatile, and fastest technique for chromatographic analysis in the field of quality control of drug components. In this review, the authors have also tried to summarize some of the advancements and recent patents in which the HPLC technique was used for the analysis. Conclusion: The article will help in understanding the role and importance of this analytical technique in the quality control of drugs and biologicals.

Keywords: Applications; Advancements; Chromatography; Detectors; High Performance Liquid Chromatography; Patents; Pumps

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