Curative Consequences of Rocket Seeds (Eruca Sativa) Extract against Lead Nanoparticles Induced Renal Dysfunction in Rats
Batoul M. Izzularab1*
, Ehab Tousson2, Nabiha I. Abdo3 and Doha M. Beltagy11Biochemistry Division, Chemistry Department, Faculty of Science, Damanhour University, Egypt.
2Department of Zoology, Faculty of Science, Tanta University, Egypt.
3Department of Basic Sciences, Higher Institute of Engineering and Technology, New Borg El-Arab City, Egypt.
Corresponding Author E-mail: batoul.izzularab@sci.dmu.edu.eg
Abstract: Lead nanoparticles (Pb-NPs) are used in different industrial aspects with potential risk in human health. The current work aimed to appreciate the therapeutic rocket seeds extract effect on against renal toxicity stimulated by (Pb-NPs) via estimation of kidney functions and electrolytes with different histological and immunological studies. Pb-NPs were synthesized by biocompatible chemical coprecipitation of Pb2+ and glucose as a reducing agent. These nanoparticles have been characterized using X-ray diffraction (XRD) and scanning electron microscopy (SEM) techniques. Pb-NPs have a relatively cubic shape with diameter about 16 nm. The study was performed on 60 male albino rats distributed into four groups (control, rocket- seeds extract, Pb-NPs, and treated) The results demonstrated the toxic effects of Pb-NPs via the destruction of the renal cell resulted in significant elevations of urea and creatinine concentrations which affected on electrolyte hemostasis. The rocket seed extract administration showed beneficial curative effects against renal toxicity induced by Pb-NPs exposure. Rocket seeds extract administration showed regression of the kidney functions and improvement of electrolytes hemostasis. These result were indicated by histopathological and immunohistochemical analysis
Keywords: Apoptosis; Electrolytes; Lead nanoparticles; Renal dysfunction; Rocket seeds extract Back to TOC