Solubility of Nifedipine by Shake Flask UV-Spectrometry; Review of Safety Concerns in Pregnancy
Soham Samajpaty
Department of General Medicine, International Faculty, Russian National Research Medical University named after NI Pirogov, Moscow, Russian Federation
Corresponding Author E-mail: sohamsamajpaty@gmail.com
Abstract: Nifedipine is chemically dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate, a dihydropyridine derivative used frequently as anti-hypertensive. It is a L- type calcium channel blocker (CCB). Few analogical discrepancies were found between Nifedipine’s clinical output report and chemical analysis of solubility. The ambition of this research is to conduct a re-check and proper quantification of partition co-efficient (logP) of Nifedipine and clarify the discrepancy and rectify if any mistake has been done in recent past. The method used is the “gold standard” shake-flask method followed by analysis through UV-scpectrophotmetry.
Keywords: logP of Nifedipine; Medicine; Nifedipine; Pharmacology; Solubility Of Nifedipine Back to TOC