Optimization of Glyceryl Polyacrylate in Nanoemulgel of Mangosteen (Garcinia mangostana L.) Rind Fraction
Ni Putu Ayu Dewi Wijayanti*
, Putu Sanna Yustiantara and I Wayan Agus WidiantaraDepartment of Pharmacy, Faculty of Mathematics and Natural Science, University of Udayana, Jimbaran, Indonesia
Corrresponding Author E-mail: dewi_wijayanti@unud.ac.id
Abstract: The mangosteen fruit rind fraction positively contains flavonoids and polyphenols which can act as an antioxidant anti-inflammatory. The use of mangosteen rind fraction in topical preparations requires a good delivery system to support percutaneous penetration, one of which is nanoemulsion. The topical use of nanoemulsion has low viscosity and to increase the penetration of active compound, therefore it needs to be formulated into nanoemulgel preparations. In formulating nanoemulgel preparations, the optimum concentration of gelling agents is needed to obtain a nanoemulgel that meets the physical and chemical characteristics of the gel preparation. Therefore we need an optimization of glyceryl polyacrylate gelling agent in order to obtain a nanoemulgel with good characteristics. Nanoemulgel for mangosteen rind fraction was made in four formulas with gelling agent concentrations of glyceryl polyacrylate as much as 1% (F1), 2% (F2), 3% (F3), and 4% (F4). The nanoemulgel has been evaluated for its physical and chemical characteristics including organoleptic test, homogeneity, adhesion, viscosity, dispersibility, and pH. The active substance release test is carried out on a gel that meets the overall requirements for physical and chemical properties. The analysis showed that the F1 produced a nanoemulgel that met the physical and chemical characteristics of the semisolid preparations. Organoleptic of F1 isi semisolid form with yellow color and typically garcinia fruit rind fraction odor, homogen mixture, 1 ± 0.02s adhesion, 8340 ± 555 viscosity, 6.87 ± 0.39 cm2 spreadability, and 6.39 ± 0.01 pH. The results of the release of active substances showed that the F1 formula was able to release 49.9% of active substances in 10 minutes and within 480 minutes was able to release 96.54% of active substances with a total flux of 5.36 µg / cm2 minutes which fulfill the release requirement.Based on these results, it can be concluded that glyceryl polyacrylate with a concentration of 1% can produce good nanoemulgel.
Keywords: Glyceryl Polyacrylate; Mangosteen; Nanoemulgel; Nanoemulsion; Release Test Back to TOC