Influence of the herbal preparation "Licorice oil" on the state of hematopoiesis in rats under ionizing irradiation
Marat Iztleuov*
, Murat Teleuov, Yerbolat Iztleuov , Samat Saparbaev, Alma Yelubayeva, Gulmira Yemzharova, Sanimgul Sambayeva, Aigul Turganbayeva and Zhanat UmirzakovaWest Kazakhstan Marat Ospanov Medical University. Aktobe, Kazakhstan
Corresponding Author E-mail: YerbolatIztleuovermar80@mail.ru
Abstract:
The radioprotective effect of the herbal preparation "Licorice oil" on the hematopoietic system and oxidative stress was studied. The experiment was carried out on 30 male Wistar rats, divided into 3 groups. The first group is control group, the second is irradiation with 6Gy, third group - a week before irradiation and two weeks after, received "Licorice oil" intragastrically at a dose of 2.5 ml/kg of body weight. Gamma irradiation significantly reduced the number of erythrocytes, hemoglobin, hematocrit, leukocytes, thrombocytes in peripheral blood and bone marrow cellularity. The frequency of micronuclei in polychromatophilic erythrocytes of the bone marrow has significantly increased. The level of lipid peroxidation in the blood increased against the background of a significant decrease in the activity of antioxidant enzymes. The introduction of "Licorice oil" for 21 days provided a protective effect. In application of "Licorice oil", there was an increase in the number of cellular elements in the peripheral blood and against the background of a decrease in the frequency of micronuclei in the bone marrow. The activity of antioxidant enzymes in blood plasma increases against the background of a decrease in the amount of peroxidation products. The herbal preparation "Licorice oil" exhibits antioxidant activity, reduces genotoxicity and cytotoxicity under gamma irradiation. "Licorice oil" can be used to prevent radiation damage.
Keywords: Blood; Bone Marrow; Gamma Radiation; Micronuclei; Oxidative Stress; Phytopreparation "Licorice Oil", Back to TOC