Effect of Dietary Ginger as Feed Additive on Gastrointestinal Integrity, Hepatic Condition and Metabolic Parameters of Female Mice
Aliaa A. Ismail1
, Dalia W. Zeidan2, Amani A. Almallah3, Aya A. Gaber4 and Heba M. A. Abdelrazek5*1Department of Pathology, Faculty of Veterinary Medicine, Suez Canal University, Ismailia, Egypt.
2Department of Home and Economics, Nutrition and Food Science Branch, Faculty of Education, Suez Canal University, Ismailia, Egypt.
3Department of Anatomy and Embryology, Faculty of Medicine, Suez Canal University, Egypt.
4Department Pharmacology Department, Faculty of Veterinary Medicine, Suez Canal University, Ismailia, Egypt.
5Department of Physiology, Faculty of Veterinary Medicine, Suez Canal University, Ismailia, Egypt,
Corresponding Author E-mail: hebaabdelrazekvet@gmail.com
Abstract:
Present work aimed to study the influence of dietary ginger inclusion in female mice on gastrointestinal integrity, hepatic condition and metabolic parameters. Thirty female mice (18± 2 g) were assigned into 3 groups; control group fed standard rodents’ basal diet, ginger 2% and ginger 5% mice were basal diet supplemented with 2% and 5% ginger powder, respectively for 30 days. Weight gain, feed conversion (FCR) and efficiency (FER) ratios were recorded. Serum liver enzymes, lipid profile, total protein and albumin were measured beside estimation of hepatic reduced glutathione (GSH) and malondialdehyde (MDA). Gastric, intestinal and hepatic histopathology were performed as well as intestinal histomorphometry. Results revealed improvement in FCR, FER and most tested biochemical parameters, in 2% ginger group than control. Hepatic MDA and GSH were significantly (P<0.05) increased and decreased, respectively in 2% ginger group. However, ginger 5% group exhibited improvement in intestinal histomorphometry while adversely affected gastric mucosa and hepatic tissue histopathology. Also increased hepatic MDA and reduced GSH were prominent in 5% ginger group along with mild gastric and hepatic lesions. The administration of dietary ginger by 2% dose could be beneficial mice model however, increasing the dose to 5% could produce adverse effects on hepatic integrity and gastric mucosa.
Keywords: Dietary; Ginger; Intestinal Histomorphometry; Liver Back to TOC