High Prevalence of Anemia among Human Immunodeficiency Virus-Infected Patients: A Cross-sectional Study in Bali-Indonesia
Sri Agung Aryastuti1*
, Sri Ratna Dewi2 and Sri Masyeni31Department of Pharmacology, Faculty of Medicine and Health Sciences, Universitas Warmadewa, Indonesia, 80235.
2Department of Clinical Pathology, Faculty of Medicine and Health Sciences, Universitas Warmadewa, Indonesia, 80235.
3Department of Microbilogy, Faculty of Medicine and Health Sciences, Universitas Warmadewa, Indonesia, 80235.
Corresponding Author E-mail: sriagungary@gmail.com
Abstract:
Anemia is a common condition found among Human Immunodeficiency Virus (HIV)-infected patients. T-cells that are infected with HIV virus can directly suppress the growth of progenitor cells in the bone marrow so that affecting the hemopoiesis resulted in anemia. These hematological abnormalities could potentially cause serious clinical implications. This study was conducted to determine the prevalence of anemia in HIV-infected patients in Bali. It was ahospital based cross-sectional studyconducted at two public hospital in Bali-Indonesia. A total of 243 medical record data from HIV-infected patients atWangaya Hospital Denpasar Bali and Sanjiwani Hospital Gianyar Bali between 2009 -2017 were included in analysis. Prevalence of anemia in antiretroviral (ART)-naïve patients and in patients on ART were 60.8% and 40.3%, respectively. Leucopenia and thrombocytopenia were found 8.2% and 9.4%, respectively, in ART-naïve group. While in patients with ART group leucopenia and thrombocytopenia were accounted for 6.9% and 4.3%, respectively. There was a significant difference in prevalence of anemia between ART-naïve patients and patients on ART (60.8% vs. 40.3%; p < 0.05). Although the prevalence of anemia was lower in patients on ART, but anemia continues to be common in a substantial portion of HIV-infected persons. Another studies are still needed to addressing the impact of anemia on HIV-infected individuals, as well as treatment strategies and future research directions.
Keywords: Anemia; Antiretroviral; Bali; HIV; Indonesia Back to TOC