Anti-Pyretic Activity of two Varieties of Hibiscus Rosa Sinensis L.
MWH Abdul Aziz1, SZ Raduan1, AH Roslida2, ZA Zakaria2, A Zuraini2 and MN Hakim2,3*.1Faculty of Medicine and Health Sciences, University Malaysia Sarawak, Lot 77, Seksyen 22,KTLD Jalan Tun Ahmad Zaidi Adruce, 93150 Kuching, Sarawak, Malaysia.
2Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 UPM Serdang Selangor, Malaysia.
3Institute of Bioscience, Universiti Putra Malaysia, 43400 UPM Serdang Selangor, Malaysia.
Corresponding Author E-mail: nazrulh@upm.edu.my
Abstract:
Hibiscus rosa-sinensis has been traditionally used by local communities to treat fever. However, there are only limited data have been published to support the antipyretic effects. The objective of this study is to investigate the antipyretic properties and possible mechanism of the ethanol extracts of Hibiscus rosa-sinensisL. (red colored flower) and Hibiscus rosa-sinensisvar. Alba (white colored flower). Phytochemical analysis, heavy metals screening and acute toxicity test were done to evaluate the safety of extracts. The first model ran induced fever in rats by injecting Brewer's Yeast subcutaneously and then treated with 4 extracts at dosage 5 & 50 mg/kg. The dosages used for the study were obtained by the acute toxicity test. Ibuprofen was used as a reference drug, with dose 100 mg/kg. Temperatures of rats were measured using a digital thermometer. The results were expressed as mean ± S.E.M. and analyzed using the SAS system. The results of the study showed that white flower extract 5mg/kg and 50 mg/kg significantly (p <0.05) reduced the total temperature when compared to positive control group. Therefore, this research suggests the probability for its therapeutic effectiveness as plant-based antipyretic agent as claimed by traditional medicine practitioners.
Keywords: Antipyretic; Hibiscus Rosa-Sinensis; Toxicity Back to TOC