Serum Carboxy Methyl Lysine, Insulin Resistance and Sensitivity in Type 2 Diabetes Mellitus and Diabetic Nephropathy Cases; an Observational Study

R Sai Deepika¹, Shashidhar KN^1*, Raveesha A² and Muninarayana C³

¹Department of Biochemistry, Sri Devaraj Urs Medical College Kolar, India

²Department of General Medicine, Sri Devaraj Urs Medical College Kolar, India

³Department of Community Medicine, Sri Devaraj Urs Medical College Kolar, India

Corresponding Author E-mail: drshashikn1971@yahoo.co.in

Abstract: Objective: Diabetes Mellitus (DM) and one of its types; type 2 diabetes mellitus (T2DM) is more prevalent from adolescent across the globe, invariable of heredity and age. Diet restriction shall cope up and help body metabolism to absorb the required nutrition and eliminate the junk out of body under healthy diet. Masking of insulin action on target cells leads to insulin resistance (IR) and decreased insulin sensitivity (IS) resulting in increased glycated products such, glycated hemoglobin, glycated albumin and other glycated macromolecules called Advanced Glycation End products. Along with AGE and diabetic profiling, BMI, insulin and lipid profiling may help elucidate the correlation between CML and glucose metabolism in diabetics and diabetic nephropathy cases. CML is formed by Glycoxidation and lipoxidation. Thereby, main objective of this study includes basic renal profiling was also performed to assess kidney functioning and finding its relation with CML. Results: Correlation of CML with important diabetic and metabolic syndrome parameters were performed, giving a supportive evidence for labeling CML as harmful molecule. CML positively correlated with HbA1c, TG and HOMA IR and negatively correlated with QUICKI in group 2 signifying increased damage to tissues due to collective action of glucose, lipid and insulin resistance. Monitoring plasma CML regularly during follow up along with HbA1c may help keep track on plasma glucose status and its deleterious effects on tissues thereby preventing erosion of tissue and vascular lining.

Keywords: Advanced Glycation Endproduct; Diet restriction; Glycated hemoglobin; Glycoxidation; HOMA IR; Lipoxidation

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