Molecular and Immunological Mechanisms of Miana Leaf (Coleus Scutellariodes [L] Benth) in Infectious Diseases

Theo Audi Yanto¹, Mochammad Hatta^2*, Agussalim Bukhari³ and Rosdiana Natzir⁴

¹Department of Internal Medicine Faculty Medicine Universitas Pelita Harapan, Tangerang, Indonesia.

²Department of Molecular Biology and Immunology, Faculty Medicine, Hasanuddin University, Makassar, Indonesia

³Department of Nutrition, Faculty Medicine Universitas Hasanuddin, Makassar, Indonesia.

⁴Department of Biochemistry, Faculty Medicine Universitas Hasanuddin, Makassar, Indonesia.

Corresponding Author E-mail: hattaram@yahoo.com

Abstract: Infectious disease is still a massive world burden of disease. It causes premature mortality and morbidity. Regardless of antibiotic therapy, the increased numbers of antibiotic resistance bring emerging problems in infectious disease. Several pathogens have unique roles to deactivate host immune response causing difficulty to treat the infection. Alack of antibiotic efficacy is crucial to modulate the immune response as a brilliant strategy to face infectious disease in years to come. Various herbal medicine has been known to have a pivotal role in enhancing immune response at the molecular level. Miana leaves extract (MLE) has a potential role in regulating the immune response to the infection. Besides its antimicrobial effect, MLE has other properties such as anti-inflammation, antioxidant. Several studies have revealedthe molecular mechanism of MLE in immune response, such as enhancing IL 37, IL 10, regulating TLR 4, and IFN-g. The objectives of this article are to review the molecular and immunological mechanism of Miana in treating various infective diseases comprehensively.

Keywords: Coleus; Infectious  Disease; Immunology; Miana; Molecular

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