High-Sensitive C-reactive Protein and Atherogenic Lipid Levels in a Group of University Students with Habitual Smoking
Ghada A Elfadil1, Elyasa M Elfaki2, Sulafa O Madani1, Ezeldine K Abdalhabib2 and Abdelgadir Elmugadam11Department of Clinical Chemistry, College of Medical Laboratory Science, Sudan University of Science and Technology, Khartoum –Sudan
2Clinical Laboratory Sciences Department, College of Applied Medical Science, Al-Qurayyat, Jouf University, Saudi Arabia.
Corresponding Author E-mail:elyasaelfaki6@gmail.com
Abstract: High-Sensitive C-reactive Protein (hs-CRP) is a well-known inflammatory and cardiovascular disease (CVD) marker. Non-HDL cholesterol concentration in blood are strongly associated with long-term risk of atherosclerotic CVD. Hs-CRP and atherogenic lipids are suggested to be a central feature of cardiovascular disease (CVD), particularly among smokers. Smoking for long duration seems to be correlated with high level of hs-CRP, plasma cholesterol and LDL-C. This study was done to evaluate the plasma levels of hs-CRP, lipid profile, and magnesium in a group of university students with habitual smoking. Eighty current smoker males participated in this cross sectional study. Estimation of plasma hs-CRP was carried out using latex immune turbidimetric method, plasma lipid profile and magnesium by chemical methods using a spectrophotometer (Biosystem 310) and results were computed by using SPSS. Regarding hs-CRP level, 20% (16/80) participants were at high (>3mg/L) risk to CVD; total cholesterol 6.3% (5/80) participants were at an average greater than 240mg/dL; LDL-C 6.3% (5/80) were at an extremely high risk of greater than 190 mg/dL. A test group of students who smokes for ten years or more had a significant increase in means of plasma hs-CRP, total cholesterol, LDL-C P value˂ 0.05, while there was a significant decrease in means of plasma HDL-C P value <0.05. Study results revealed that cigarette smoke was associated with considerable changes of hs-CRP, and atherogenic lipids that were considered as risk factors for cardiovascular disease among young male smokers.
Keywords: Smoker; hs-CRP; Total cholesterol; LDL-C; CVD; magnesium; Students Back to TOC