Antibacterial Activity of Clinacanthus nutans Polar and Non-Polar Leaves and Stem Extracts
Swee-Hua Erin Lim1*, Maitha Ahmed Almakhmari1, Shaima Ibrahim Alameri1, Swee-Yee Chin2, Aisha Abushelaibi1, Chun-Wai Mai 2,3 and Kok-Song Lai11Health Sciences Division, Abu Dhabi Women’s College, Higher Colleges of Technology, Abu Dhabi, United Arab Emirates, 41012
2Department of Pharmaceutical Chemistry, School of Pharmacy, International Medical University, Kuala Lumpur, Malaysia, 57000
3Centre for Cancer and Stem Cells Research, Institute for Research, Development and Innovation, International Medical University, Kuala Lumpur, Malaysia, 57000
Corresponding Author E-mail: lerin@hct.ac.ae
Abstract: Clinacanthus nutans is widely used as an antimicrobial, anti-inflammatory, anti-pyretic and cytotoxic agent in Asian countries such as Thailand and Malaysia. Our previous study suggested C. nutans may exhibit anti-inflammatory effects. However, there are limited studies at current for the antimicrobial affect for this plant; hence this study was carried out to investigate the minimum inhibitory concentration (MIC) of C. nutans polar and non-polar leave and stem extracts against twelve gram- negative and positive bacteria. Briefly, the plant parts were separated, dried and powdered, then the extracts were prepared as polar and non-polar extracts from leaves and stem. The result showed inhibition effects in all of the bacteria tested. Our findings from this study indicated that non-polar leaves extracts are more potent as an antimicrobial agent compared to polar leaves, non-polar stem and polar stem. Future studies are warranted for further identification of bioactive compounds in C. nutans with anti-bacterial activities.
Keywords: Antibacterial; Antimicrobial activity; Anti-inflammator; Bacterial resistance; Clinacanthus nutans; Natural product. Back to TOC